Background: Polyethylene covers are claimed to be useful in preventing ocular surface diseases (OSD); however, evidence of their clinical efficacy is limited. This clinical trial aimed to compare the use of polyethylene eye covers and artificial teardrops versus normal saline on the incidence and severity of OSD in comatose patients.
Methods: Of 90 eligible patients randomly assigned to three treatment groups, 79 patients completed the study, In group A, patients (n = 25) received artificial teardrops for left and normal saline for right eyes, in group B (n = 29) polyethylene covers for left and normal saline for right eyes, and in group C (n = 25) polyethylene covers for left and artificial teardrops for right eyes. As the patients were comatose, their blinding did not applicable, and a blinded observer evaluated the patients' eyes based on the Corneal Fluorescein Staining Pattern. The blinded analyzer analyzed collected data by SPSS-16 software at a 95% confidential level.
Results: The OSDs were observed in 65 (41.14%) out of 158 eyes examined. The artificial teardrop was more effective than the normal saline in group A, polyethylene eye cover was more useful than the normal saline in group B, and polyethylene eye cover was more effective than the artificial teardrop in group C in reducing the incidence of OSD (p< 0.01). Polyethylene eye covers had the most impact on reducing the severity of the OSD compared to the other interventions (p< .001).
Conclusions: Polyethylene eye covers significantly reduced the incidence and severity of OSD. Using polyethylene cover is suggested as a safe, effective, and accessible eye care intervention for preventing OSD in comatose patients.
Trial Registration: (IRCT201609129014N115), Iranian Registry of Clinical Trials.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016328 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248830 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Detection of microplastics in pterygium tissue: Implications for environmental hazards.
Eur J Ophthalmol
January 2025
Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea.
Purpose: This study aimed to report a case of microplastics (MPs) detection in a pterygium patient's tissue.
Case Report: A pterygium specimen was obtained from the right eye of a 43-year-old woman by surgical removal of a recurred pterygium. The number, morphology, and material type of the MPs in pterygium were identified using Raman microscopy and scanning electron microscopy.
Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.
Nat Commun
January 2025
Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, PR China.
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery system, named Ionizable Polymeric Micelles (IPMs). The siRNA encapsulated IPMs escape from lysosomes upon cellular uptake, and silence the target gene.
View Article and Find Full Text PDFArticle Synopsis
- Histology is crucial for examining tissue structure and cell details, but standard methods for cryosectioning small tissues like organoids lack efficiency and cost-effectiveness, hindering analysis.
- The adapted HistoBrick method uses an optimal embedding mixture of 8% PEGDA and 2.5% gelatine, providing support for fragile samples during cryosectioning and preserving delicate structures of human retinal organoids.
- Using these PEGDA-gelatine HistoBricks, researchers monitored retinal organoid development over time, finding that photoreceptor cell bodies were sustained for up to 98 weeks, although outer segments diminished, making this approach valuable for increased throughput in tissue studies and research.
Postoperative Outcomes of Enucleation without Closure of the Conjunctiva.
Ophthalmic Plast Reconstr Surg
October 2024
Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.
Purpose: To evaluate the long-term outcomes of enucleation without conjunctival closure in a large patient cohort.
Methods: A retrospective chart review was conducted from January 2011 to January 2024, examining 144 eyes of 143 patients who underwent enucleation without conjunctival closure by a single oculoplastic surgeon. Data collected included patient demographics, indications for surgery, implant types, and complications.
Effect of different artificial tears on tear film parameters in dry eye disease.
Optom Vis Sci
December 2024
Department of Biostatistics, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Significance: Artificial tears remain the cornerstone for managing dry eye disease. The current study's real-world efficacy test of carboxymethylcellulose (CMC), polyethylene glycol (PEG) 400, or sodium hyaluronate (SH)-based lubricants highlights their similar effects on noninvasive tear film parameters over the short term. However, patients reported better relief with SH-based lubricants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!