Aim: Children with Down syndrome (DS) have delayed development and atypical movements including kicking. We hypothesized that a kicking intervention would significantly increase leg movement rate.
Methods: Nine infants, 3-5 months old, with DS used a commercially available toy that encouraged kicking. The intervention was administered in their home for 20 minutes, 5 days a week, for 8 weeks. Leg movement rate was measured using Opal wearable sensors before and after the intervention. At post-test, a secondary analysis compared infants with DS to infants with typical development (TD).
Results: Average leg movement rate increased significantly from pre to post intervention, from 2253 to 2645 movements per hour of awake time ( = 0.049). Compared to data from nine infants with TD, infants with DS had a significantly lower movement rate post intervention ( = 0.002).
Conclusion: The infants with DS demonstrated a higher leg movement rate following an in-home kicking intervention.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478830 | PMC |
http://dx.doi.org/10.1080/01942638.2021.1889735 | DOI Listing |
Sleep
January 2025
Clinical Neurophysiology Research Unit and Sleep Research Centre, Oasi Research Institute-IRCCS, Troina, Italy.
Study Objectives: This study aimed to investigate the effect of dopamine agonists (DA) and Clonazepam on Large Muscle Group Movements during sleep (LMM), a distinct motor phenomenon, in Restless Legs Syndrome (RLS).
Methods: A retrospective analysis was conducted on 51 drug-free adult patients with RLS, divided into three groups: 33 received a DA (pramipexole or ropinirole), 15 received clonazepam, and 18 received a placebo. Each patient underwent two consecutive nocturnal polysomnographic (PSG) recordings: one baseline and one following treatment administration.
Background: People living with dementia (PWD) often have inactivity-induced muscle atrophy, increased sedentary behavior, and circadian rhythm disorders. Exercise may improve physical activity, sedentary behavior, and sleep in PWD, but further research is needed. The purpose of this pilot randomized controlled trial (RCT) was to examine whether a structured exercise program improves physical activity, sedentary behavior, and sleep in PWD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Background: The Exercise and Intensive Vascular Risk Reduction in Preventing Dementia (rrAD study) was a multicenter randomized, controlled trial to determine the effects of moderate to vigorous aerobic exercise training and intensive pharmacological treatment of cardiovascular risk factors on dementia prevention in older adults (NCT02913664). The trial duration was 2 years. We present herein the adverse events (AEs) reported in the rrAD trial.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of (South).
Background: This study delves into the relationship between gait disturbances and the progression of Alzheimer's disease (AD), focusing on how these changes correlate with cognitive impairments and key neuropathological indicators.
Method: We prospectively enrolled 48 patients with AD dementia (ADD), 27 patients with prodromal AD (proAD), and 41 cognitively unimpaired (CU) individuals between January 2022 and May 2023. Participants underwent brain T1-weighted MRI, F-florbetaben PET, neuropsychiatric tests, and APOE genotyping, and quantified gait analysis was assessed using a 5.
Clin Transl Sci
January 2025
Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Exercise increases blood and lymph flow in working muscles, potentially affecting the bioavailability and effect of subcutaneously administered drugs. The aim of this study was to assess the influence of a single exercise session on pharmacokinetics and pharmacodynamics of a single dose of subcutaneously administered unfractionated heparin. In a crossover design, 15 healthy males underwent four experimental days where 15,000 IU of unfractionated heparin was injected subcutaneously into the thigh of the non-dominant leg.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!