Chronic kidney disease (CKD) is a serious health problem with high morbidity and mortality, mainly attributable to cardiovascular risk. is traditionally used in Cameroon for the management of cardiovascular diseases. The aim of this study was to evaluate the cardioprotective and nephroprotective effects of the aqueous extract from the stem bark of . (AEGL). The in vitro antioxidant effect of AEGL was assessed at concentrations ranging 1-300 g/mL against DPPH, lipid peroxidation, and AAPH-induced hemolysis. The reducing power and phenolic and flavonoids contents were also determined. CKD was induced by intraperitoneal bolus injection of adenine (50 mg/kg/day) for 4 consecutive weeks to male Wistar rats. AEGL (150 and 300 mg/kg/day) or captopril (20 mg/kg/day) was concomitantly administered with adenine per os. Bodyweight and blood pressure were monitored at baseline and weekly during the test. At the end of the experiment, plasma creatinine, urea, AST, and ALT were quantified. Proteinuria, creatinine excretion, and creatinine clearance were also assessed. The effect on GSH, CAT, and SOD activity was evaluated in cardiac and renal homogenates. Sections of the heart and kidney were stained with hematoxylin and eosin. AEGL exhibited a potent in vitro antioxidant activity and was shown to possess a large amount of phenolic compounds. Adenine alone increased blood pressure, cardiac and kidney mass, proteinuria, protein to creatinine ratio, plasma creatinine, AST, and urea levels ( < 0.05, 0.01, and 0.001). Besides, the bodyweight and creatinine clearance were significantly reduced ( < 0.05 and < 0.01). All these alterations were blunted by the plant extract, except the bodyweight loss. In addition, AEGL improved GSH levels and CAT and SOD activities. AEGL attenuated adenine-induced glomerular necrosis, tubular dilatation, and cardiac inflammation. AEGL exhibits cardioprotective and nephroprotective effects that may be ascribed to its antihypertensive and antioxidant activities.
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http://dx.doi.org/10.1155/2021/5581041 | DOI Listing |
Chem Biodivers
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Mohammed First University Oujda Faculty of Science: Universite Mohammed Premier Oujda Faculte des Sciences, biology, 60000, Oujda, Oujda, MOROCCO.
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Center for Nephrology "G. Papadakis", General Hospital of Nikaia-Piraeus "Ag. Panteleimon", 18454 Nikaia, Greece.
G Ital Nefrol
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Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
In recent years, the prevalence of chronic kidney disease (CKD) has significantly increased, with an estimated 843.6 million individuals affected in 2017 [1]. This rise is closely linked to the growing incidence of risk factors such as diabetes mellitus and obesity.
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June 2024
Humanitas Gavazzeni e Castelli, Bergamo, Italy.
Sweet Heart and Light Heart represent the first two educational formats of ITACARE-P, a recently established scientific association that joins various professionals with the aim of promoting all activities related to Cardiac Prevention and Rehabilitation. These educational formats represent opportunities for updating, comparing and sharing ideas among experts in order to standardize behaviors on hot topics. Pathologies in the metabolic field were chosen: diabetes mellitus and obesity, especially due to the cardiologist's possibility of prescribing drugs belonging to the SGLT2-i and GLP-RA classes, which have been shown to have a cardioprotective and nephroprotective effect, thus carrying a favorable influence on cardiovascular mortality.
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June 2024
Service de néphrologie-dialysetransplantation, CHU, Nice, France.
RENIN-ANGIOTENSINALDOSTERONE SYSTEM BLOCKADE AND BEYOND. Patients with chronic kidney disease (CKD) require both etiological and symptomatic treatments to slow renal function decline. Reductions of protein and salt intakes are required.
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