AI Article Synopsis
- Epithelial-mesenchymal transition (EMT) is a process where epithelial cells change to a more migratory and invasive mesenchymal state, playing key roles in both normal body functions and tumor development.
- In pituitary tumors, which are usually benign but can be locally invasive, EMT has been linked to larger tumor size and higher invasion rates, as well as poor responses to treatment with Somatostatin Receptor Ligands (SRLs), particularly in growth hormone-producing tumors associated with acromegaly.
- This review aims to consolidate what is known about EMT and SRLs resistance in acromegaly and proposes potential new biomarkers and therapies targeting SRLs resistant tumors.
Article Abstract
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. Pituitary tumors, although typically benign, can be locally invasive. Different studies have shown the association of EMT with increased tumor size and invasion in pituitary tumors, and in particular with a poor response to Somatostatin Receptor Ligands (SRLs) treatment in GH-producing pituitary tumors, the main cause of acromegaly. This review will summarize the current knowledge regarding EMT and SRLs resistance in acromegaly and, based on this relation, will suggest new biomarkers and possible therapies to SRLs resistant tumors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006574 | PMC |
| http://dx.doi.org/10.3389/fendo.2021.646210 | DOI Listing |
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