This study investigated major allelic variants of and in Egyptians, an Arabic population for which there is little information regarding these important pharmacogenes. , , , , and gene copy number variation, as well as and were determined with commercially available TaqMan assays in 145 healthy study participants. The alleles identified suggest that the prevalence of poor metabolizers is low as none were found among the 145 subjects investigated. The frequency for nonexpressers was 74.5% and the allele frequency was low at 2.0%. These preliminary findings indicate that pharmacogene variation in Egyptians is different from those of other Middle Eastern/Arabic populations and warrants further investigation.
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