Spinal cord stimulation (SCS) has been used to treat sustained pain that is intractable despite various types of treatment. However, conventional tonic waveform SCS has not shown promising outcomes for spinal cord injury (SCI) or postamputation pain. The pain signal mechanisms of burst waveforms are different to those of conventional tonic waveforms, but few reports have presented the therapeutic potential of burst waveforms for the abovementioned indications. This current case report describes two patients with refractory upper limb pain after SCI and upper limb amputation that were treated with burst waveform SCS. While the patients could not obtain sufficient therapeutic effect with conventional tonic waveforms, the burst waveforms provided better pain reduction with less discomfort. However, further studies are necessary to better clarify the mechanisms and efficacy of burst waveform SCS in patients with intractable pain.
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http://dx.doi.org/10.1177/03000605211004035 | DOI Listing |
Braz J Vet Med
January 2025
Veterinarian, Neurology Department, AniCura Istituto Veterinario di Novara, Granozzo con Monticello, Novara, Italy.
An 11-year-old male Bengal tiger () was referred for a 2-week history of ambulatory tetraparesis, generalized ataxia, and hypermetric gait, associated with mild right head tilt and spontaneous proprioceptive deficit on the right forelimb. Neuroanatomical localization was C1-C5 myelopathy; cerebellum-vestibular system involvement was also considered. Hematology and serum biochemistry were unremarkable, although serum vitamin A (0.
View Article and Find Full Text PDFFront Neurol
December 2024
The Second School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Objective: Sciatic nerve injuries often lead to severe pain and motor dysfunction, causing serious impact on patients' quality of life. Acupuncture, as one of the main therapies in traditional Chinese medicine, is gradually gaining attention in the field of nerve injury due to its potential role in pain relief and nerve repair. Bibliometric and scientific knowledge mapping methods were employed to analyze the current research status, hotspots, and development trends of acupuncture for sciatic nerve injury (SNI) over the past decade.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, Merit Health Wesley, Hattiesburg, USA.
Anterior cord syndrome is a rare yet critical neurological condition that poses significant challenges in clinical management. We present the case of a 71-year-old male with a medical history of hypertension, uncontrolled type II diabetes mellitus, hypothyroidism, and end-stage renal disease requiring dialysis who presented to the emergency department with complaints of chills, back pain, abdominal pain, and vomiting episodes. Based on the severity of the patient's illness, it was decided that inpatient admission would be best.
View Article and Find Full Text PDFNeurol Genet
February 2025
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
In the late 1800s, Nikolaus Friedreich first described "degenerative atrophy of the posterior columns of the spinal cord," noting its connection to progressive ataxia, sensory loss, and muscle weakness, now recognized as Friedreich ataxia (FRDA). Renewed interest in the disease in the 1970s and 80s by the Quebec Cooperative Group and by Anita Harding led to the development of clinical diagnostic criteria and insights into associated biochemical abnormalities, although the primary defect remained unknown. In 1988, Susan Chamberlain mapped FRDA's location on chromosome 9.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Department of Kinesiology, Trent University, Peterborough, ON, Canada.
Previous research on resting muscles has shown that inter-pulse interval (IPI) duration influences transcranial magnetic stimulation (TMS) responses, which can introduce serious confounding variables into investigations if not accounted for. However, it is far less clear how IPI influences TMS responses in active muscles. Thus, the purpose of this study was to examine the relationship between IPI and corticospinal excitability during submaximal isometric elbow flexion.
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