AI Article Synopsis
- Right ventricular hypertrophy (RVH) is linked to high pressure conditions like tetralogy of Fallot and pulmonary stenosis, leading to changes in energy metabolism and gene regulation.
- This study identifies various previously unknown non-coding RNAs in human RVH, which are involved in regulating genes related to glucose/lipid metabolism, cell interactions, apoptosis, and extracellular matrix composition.
- It represents the first comprehensive RNA sequencing of compensated human RVH, improving our understanding of how the heart adapts and revealing potential therapeutic targets for treatment.
Article Abstract
Right ventricular hypertrophy (RVH) occurs in high pressure afterload, e.g., tetralogy of Fallot/pulmonary stenosis (TOF/PS). Such RVH is associated with alterations in energy metabolism, neurohormonal and epigenetic dysregulation (e.g., microRNA), and fetal gene reprogramming in animal models. However, comprehensive expression profiling of competing endogenous RNA in human RVH has not been performed. Here, we unravel several previously unknown circular, long non-coding, and microRNAs, predicted to regulate expression of genes specific to human RVH in the non-failing heart (TOF/PS). These genes are significantly overrepresented in pathways related to regulation of glucose and lipid metabolism (SIK1, FABP4), cell surface interactions (THBS2, FN1), apoptosis (PIK3IP1, SIK1), extracellular matrix composition (CTGF, IGF1), and other biological events. This is the first unbiased RNA sequencing study of human compensated RVH encompassing coding and non-coding RNA expression and predicted sponging of miRNAs by non-coding RNAs. These findings advance our understanding of adaptive RVH and highlight future therapeutic targets.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994198 | PMC |
| http://dx.doi.org/10.1016/j.isci.2021.102232 | DOI Listing |
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