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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987902 | PMC |
| http://dx.doi.org/10.1016/j.hrcr.2020.12.007 | DOI Listing |
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First-in-human trial of atrial fibrillation ablation using real time tissue optical assessment to predict pulsed field lesion durability.
Europace
January 2025
Division of Cardiology, McGill University Medical Center, Montreal, Quebec, Canada.
Background: Loss of bipolar electrograms immediately after pulsed field ablation (PFA) makes lesion durability assessment challenging.
Objective: The aim of this trial (NCT06700226) was to evaluate a novel ablation system that can optically predict lesion durability by detecting structural changes in the tissue during ablation.
Methods: Patients with paroxysmal atrial fibrillation underwent pulmonary vein isolation (PVI) using PFA (AblaView®, MedLumics).
Emerging role of spasmolytic polypeptide-expressing metaplasia in gastric cancer.
J Gastrointest Oncol
December 2024
Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.
Gastric cancer (GC) ranks among the top five most diagnosed cancers globally, with particularly high incidence and mortality rates observed in Asian regions. Despite certain advancements achieved through early screening and treatment strategies in many countries, GC continues to pose a significant public health challenge. Approximately 20% of patients infected with develop precancerous lesions, among which metaplasia is the most critical.
View Article and Find Full Text PDFGastric Antral Vascular Ectasia Syndrome With Aortic Stenosis: A Twist on Heyde Syndrome?
J Med Cases
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Gastroenterology and Hepatology, St. Joseph's University Medical Center, Paterson, NJ, USA.
Heyde syndrome is a triad of aortic stenosis (AS), gastrointestinal (GI) bleeding from angiodysplasia, and acquired von Willebrand disease (vWD). It is hypothesized that stenotic aortic valves cleave von Willebrand factor (vWF) multimers, predisposing patients to bleeding from GI angiodysplasias. This hypothesis is supported by the observation that aortic valve replacement often leads to the resolution of GI bleeding.
View Article and Find Full Text PDFIntestinal metaplasia key molecules and UPP1 activation via Helicobacter pylori /NF-kB: drivers of malignant progression in gastric cancer.
Cancer Cell Int
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Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Gastric cancer (GC) remains a significant global health challenge due to its high morbidity and mortality rates. The development of GC is a multi-hit process and the exploration of precancerous lesions is crucial. To elucidate the molecular and cellular dynamics underlying gastric carcinogenesis, we conducted an integrative single-cell RNA sequencing analysis of 26,028 high-quality cells from gastric antral mucosa biopsies across various stages, including non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, and early gastric cancer.
View Article and Find Full Text PDFChemotherapy combined with immunotherapy in a patient with multiple primary gastric and rectal cancers with good prognosis: A case report.
Medicine (Baltimore)
November 2024
Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Article Synopsis
- The article discusses the complexities of diagnosing multiple primary cancers and emphasizes the importance of genetic testing, specifically next-generation sequencing (NGS), in aiding this process.
- A 74-year-old male patient was diagnosed with rectal and gastric adenocarcinomas, and following comprehensive testing, he received personalized treatment that included chemotherapy and immunotherapy.
- The patient's successful outcome, with a complete remission of gastric lesions, illustrates the vital role of tailored treatment strategies based on genetic testing for managing multiple primary cancers.
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