Unlabelled: Prostate cancer (PCa), the most common solid malignant neoplasm in men, is characterized using the Gleason score and diagnosed using prostate-specific antigen (PSA) biomarker. However, Gleason score and PSA-based diagnostics are not universal and have significant limitations. It is supposed that the ornithine decarboxylase activity (A) could be a suitable auxiliary biomarker for the PCa diagnosis or monitoring the therapeutic efficacy.
Aim: To assess the relation between A in PCa tissues and the level of serum PSA with the Gleason score (GS) and the clinical stage.
Materials And Methods: 29 patients (48 to 79 years old) with prostate adenocarcinoma of different GS (6 to 10) and clinical stage (T1 to T4) were enrolled in the study. The A was analyzed in the PCa tissues by the modified spectrophotometric assay.
Results: The patients with PCa were distributed into two groups: with low A < 0.3 and high A > 0.45. In group with A < 0.3, the highest value of A was recorded in patients with the lowest GS (= 6), while in group with A > 0.45, the highest value of A was recorded in the patients with the highest GS (= 9-10). Furthermore, in group with A > 0.45, the highest value of A was registered in the patients with T1 or T4 stage. The highest levels of serum PSA were detected in T3-T4 cases and in cases with the highest GS.
Conclusion: The patterns of A and serum PSA can be used as supplementary indices useful for monitoring PCa course.
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| http://dx.doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-1.16011 | DOI Listing |
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