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Analyzing skin tumor development in mice by the DMBA/TPA model. | LitMetric

Analyzing skin tumor development in mice by the DMBA/TPA model.

Methods Cell Biol

BRIC, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Published: November 2021

AI Article Synopsis

Article Abstract

Mice are the most important animals to model tumor formation and malignant progression in humans. Chemical induction of skin tumors in mice by treatment with DMBA and TPA is a well-studied tumor induction model that is easy to use and directly applicable to genetically modified mice without any mandatory crossing with mice carrying mutations in oncogenes and tumorsuppressors. This article describes the basic protocol for DMBA/TPA induced skin tumor formation and discusses the advantages and limitations of this model, in particular the translatability of results obtained in this system to human cancer patients.

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.mcb.2020.08.004DOI Listing

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