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Development, Validation and Application of a UHPLC-MS Method for the Quantification of Chios Mastic Gum Triterpenoids in Human Plasma. | LitMetric

AI Article Synopsis

  • Chios mastic gum, a resin from a shrub native to Chios, Greece, has been used since ancient times for treating gastrointestinal issues and is now recognized by the EMA as an herbal medicine.
  • The main active compounds, isomasticadienonic acid and masticadienonic acid, are difficult to isolate in high purity, limiting pharmacological research on their biological effects.
  • This study involved a detailed analysis and successful isolation of these compounds using advanced techniques, enabling monitoring of their presence in human plasma, which could help enhance the understanding of their health benefits like anti-inflammatory and antioxidant properties.

Article Abstract

Chios mastic gum is the resinous secretion obtained from the barks of the shrub var. , which is endemic to the Greek island of Chios. Since antiquity, Chios mastic gum has found several uses as a phytotherapeutic remedy, primarily for the treatment of gastrointestinal disorders while recently, Chios mastic gum was also recognized by EMA as an herbal medicinal product with specific indications. Chios mastic gum's biological properties are attributed to triterpenes which comprise the major chemical group (approx. 70%) and notably isomasticadienonic acid and masticadienonic acid. However, due to their structural characteristics, the isolation thereof in high yield and purity is challenging and since they are not commercially available, pharmacological studies aiming to assess their biological properties are limited. In the present work, mastic's phytochemical investigation by UPLC-HRMS is followed by the isolation and characterization of isomasticadienonic acid and masticadienonic acid to be used as analytical standards for their accurate and reliable quantification in human plasma. A UHPLC-tQ-MS method that was developed and validated (in terms of specificity, linearity, limit of quantification, accuracy and precision), for the direct quantification of the targeted compounds in the low ng/mL range of concentration, was subsequently implemented on plasma samples of healthy volunteers thus demonstrating its fitness for purpose. The results presented herein might provide insight to the understanding of this traditional natural product consumed notably for its anti-inflammatory, antioxidant and lipid lowering properties. Moreover, this method might serve as a starting point for any study aiming to monitor bioactive triterpenes in biological fluids.

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Source
http://dx.doi.org/10.1055/a-1408-9338DOI Listing

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