AI Article Synopsis
- Metabolic engineering involves modifying cells to produce valuable compounds by altering or introducing genes for specific enzymatic reactions.
- Dynamic regulation of metabolic processes helps manage the competing demands on cells caused by these engineered pathways.
- The review discusses strategies for dynamic regulation, including how responsive control circuits are designed to optimize shifts in metabolic activity based on specific challenges.
Article Abstract
Metabolic engineering reprograms cells to synthesize value-added products. In doing so, endogenous genes are altered and heterologous genes can be introduced to achieve the necessary enzymatic reactions. Dynamic regulation of metabolic flux is a powerful control scheme to alleviate and overcome the competing cellular objectives that arise from the introduction of these production pathways. This review explores dynamic regulation strategies that have demonstrated significant production benefits by targeting the metabolic node corresponding to a specific challenge. We summarize the stimulus-responsive control circuits employed in these strategies that determine the criterion for actuating a dynamic response and then examine the points of control that couple the stimulus-responsive circuit to a shift in metabolic flux.
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| http://dx.doi.org/10.1146/annurev-chembioeng-091720-125738 | DOI Listing |
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