AI Article Synopsis
- - New research reveals that acute myocardial infarction (AMI) heightens inflammation and MMP-9 activity in the kidney, underscoring a need for better understanding of this response.
- - A study involving swine showed that using Impella support before heart reperfusion decreased MMP-9 levels and reduced kidney damage compared to ischemia-reperfusion or VA-ECMO methods.
- - Impella support not only lessened heart injury but also mitigated harmful kidney signaling pathways, suggesting it may offer protective benefits during cardiac events like AMI.
Article Abstract
New mechanistic insight into how the kidney responds to cardiac injury during acute myocardial infarction (AMI) is required. We hypothesized that AMI promotes inflammation and matrix metalloproteinase-9 (MMP9) activity in the kidney and studied the effect of initiating an Impella CP or veno-arterial extracorporeal membrane oxygenation (VA-ECMO) before coronary reperfusion during AMI. Adult male swine were subjected to coronary occlusion and either reperfusion (ischemia-reperfusion; IR) or support with either Impella or VA-ECMO before reperfusion. IR and ECMO increased while Impella reduced levels of MMP-9 in the myocardial infarct zone, circulation, and renal cortex. Compared to IR, Impella reduced myocardial infarct size and urinary KIM-1 levels, but VA-ECMO did not. IR and VA-ECMO increased pro-fibrogenic signaling via transforming growth factor-beta and endoglin in the renal cortex, but Impella did not. These findings identify that AMI increases inflammatory activity in the kidney, which may be attenuated by Impella support.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983528 | PMC |
| http://dx.doi.org/10.1007/s12265-021-10114-y | DOI Listing |
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