Pararamosis is a medical condition, described in the latex extracting areas of the Amazon (rubber tree regions), resulting from contact with the caterpillar of the Premolis semirufa moth. The disease can present itself in an acute form-similarly to other erucisms (injuries caused by moth larvae in humans)-or in a chronic form, typically characterized by the occurrence of changes in the joints of the hands. Because of its importance, in the context of tropical diseases, the objective of this article was to review the main facets of the disease, emphasizing the different pathogenic aspects of the interaction between the arthropod and man.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103492 | PMC |
| http://dx.doi.org/10.4269/ajtmh.20-1405 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pararamosis, a Neglected Tropical Disease Induced by Caterpillar Toxins: Investigating Their Effects on Synovial Cell Inflammation.
Int J Mol Sci
December 2024
Immunochemistry Laboratory, Instituto Butantan, São Paulo 05503-900, Brazil.
Pararamosis, also known as Pararama-associated phalangeal periarthritis, is a neglected tropical disease primarily affecting rubber tappers in the Amazon region. It is caused by contact with the urticating hairs of the moth caterpillar, which resides in rubber plantations. The condition is marked by the thickening of the articular synovial membrane and cartilage impairment, features associated with chronic synovitis.
View Article and Find Full Text PDFPararamosis: Disease of the Rubber Plantations.
Am J Trop Med Hyg
March 2021
3Department of Animal Biology, Universidade Federal de Viçosa (UFV), Viçosa, Brazil.
Pararamosis is a medical condition, described in the latex extracting areas of the Amazon (rubber tree regions), resulting from contact with the caterpillar of the Premolis semirufa moth. The disease can present itself in an acute form-similarly to other erucisms (injuries caused by moth larvae in humans)-or in a chronic form, typically characterized by the occurrence of changes in the joints of the hands. Because of its importance, in the context of tropical diseases, the objective of this article was to review the main facets of the disease, emphasizing the different pathogenic aspects of the interaction between the arthropod and man.
View Article and Find Full Text PDFIntegrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease.
Sci Rep
January 2021
Laboratório de Imunoquímica, Instituto Butantan, São Paulo, Brazil.
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA).
View Article and Find Full Text PDFHuman Chondrocyte Activation by Toxins From , an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature.
Front Immunol
May 2021
Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Article Synopsis
- Pararamosis is a disease caused by contact with the hairs of the Brazilian moth, leading to joint inflammation and cartilage damage that mimics conditions like osteoarthritis and rheumatoid arthritis.
- The study investigated the toxic effects of caterpillar hair extract on human chondrocytes, focusing on inflammatory markers like cytokines and matrix metalloproteinases (MMPs), using techniques like RT-qPCR and RNA-seq.
- Results showed increased levels of inflammatory proteins and a decrease in cartilage components, indicating a significant impact of the hair extract on cartilage health and suggesting potential pathways for treating the inflammatory response associated with this disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!