Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rec.2021.03.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A novel and sensitive trefoil-structured biosensor based on nanoporous gold for simultaneous determination of microRNA-21 and microRNA-16.
Biosens Bioelectron
December 2024
State Key Laboratory of Quality Research in Chinese Medicines & School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address:
Although electrochemical biosensors have been developed to detect multiple microRNAs (miRNAs) simultaneously through loading different capture probes, high surface-induced perturbation and competition among probes have reduced the detection sensitivity. To address these challenges, a trefoil DNA capture probe (TDCP) was designed for microRNA-21 (miR-21) and microRNA-16 (miR-16) detection simultaneously. The TDCP exhibits a stable structure, low spatial resistance, and integral rigidity, which decreases high surface-induced perturbations and competition to improve the accessibility of the target miRNA.
View Article and Find Full Text PDFMesenchymal Stem Cells Prevent SLC39A14-Dependent Hepatocyte Ferroptosis through Exosomal miR-16-5p in Liver Graft.
Adv Sci (Weinh)
December 2024
Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China.
Ischemia-reperfusion injury (IRI) is the leading cause of hepatic graft dysfunction, resulting from hepatocyte damage. Nevertheless, given the few specialized therapeutics available in hepatic IRI, additional mechanistic insights into hepatocyte damage are required. Here, the protein solute carrier family 39 member 14 (SLC39A14) is identified as a pro-ferroptosis target in hepatocytes of human liver allografts through single-cell RNA sequencing analysis.
View Article and Find Full Text PDFThe ameliorative effect of pioglitazone against colistin-induced nephrotoxicity is mediated by inhibition of NF-κB and restoration of Nrf2 signaling: An integrative bioinformatics prediction-guided in vitro study.
PLoS One
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Pioglitazone, an anti-diabetic drug, has been previously shown to ameliorate kidney damage through anti-inflammatory and antioxidant effects. In this study, we employed an integrative bioinformatics approach to study the possible mechanisms involved in the mitigative effect of pioglitazone against colistin-induced nephrotoxicity. Next, we validated the results obtained from the bioinformatics study by pre-treating human kidney-2 (HK-2) cell line with pioglitazone 100 μM for 30 minutes and then treating the cells with colistin sulfate 1200 μM for 24 hours.
View Article and Find Full Text PDFDanShen Decoction targets miR-93-5p to provide protection against MI/RI by regulating the TXNIP/NLRP3/Caspase-1 signaling pathway.
Phytomedicine
December 2024
Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, PR China; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310000, PR China. Electronic address:
Article Synopsis
- Bone marrow mesenchymal stem cells (BMSCs) exosomes have shown promise in treating heart injuries caused by ischemia/reperfusion, and this study investigates how Danshen decoction (DSD) enhances their therapeutic effects on such injuries in both lab settings and animal models.
- * Researchers identified specific microRNAs (miRNAs) that were influenced by DSD and impacted the TXNIP signaling pathway, assessing the effectiveness of different treatments involving BMSCs-exosomes in rat models of myocardial injury.
- * Results indicated that DSD pretreatment significantly increased the expression of certain miRNAs, particularly miR-93-5p, which in turn improved heart function and reduced cellular injury and inflammation associated with oxidative stress and apoptosis.*
Identification of potential hub genes associated with recurrent miscarriage through combined transcriptomic and proteomic analysis.
Biomol Biomed
October 2024
Shanghai Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.
Recurrent miscarriage (RM) is currently difficult to prevent and treat due to a lack of comprehensive understanding of its molecular mechanisms. The aim of this study was to identify genes potentially involved in the pathogenesis of RM and to observe their expression in the decidual tissues of RM patients. A total of 1823 differentially expressed genes (DEGs) and 148 differentially expressed proteins (DEPs) in decidual tissues between RM and control groups were identified.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!