We present the case of a male patient with severe SARS-CoV-2 pneumonia, with simultaneous onset of p-ANCA positive rapidly progressive glomerulonephritis. We discuss the different therapeutic possibilities, emphasising the appropriateness of their administration according to the time in the course of the infection.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843118 | PMC |
http://dx.doi.org/10.1016/j.nefro.2020.12.006 | DOI Listing |
Plants (Basel)
December 2024
Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Peking University Institute of Advanced Agricultural Sciences, Weifang 261000, China.
The acquisition and utilization of cell walls have fundamentally shaped the plant lifestyle. While the walls provide mechanical strength and enable plants to grow and occupy a three-dimensional space, successful sessile life also requires the walls to undergo dynamic modifications to accommodate size and shape changes accurately. Plant cell walls exhibit substantial mechanical heterogeneity due to the diverse polysaccharide composition and different development stages.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Late-onset Alzheimer's disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative disease that associates with aging and is highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for the use of sodium thiosulfate (STS) as a possible multi-targeting treatment option for LOAD. Sulfur is widely available in our environment and is responsible for forming organosulfur compounds that are known to be associated with a wide range of biological activities in the brain.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
The Research Institute, The McGill University Health Center, Montreal, QC H4A 3J1, Canada.
Glioblastoma multiforme is an aggressive malignancy with a dismal 5-year survival rate of 5-10%. Current therapeutic options are limited, due in part to drug exclusion by the blood-brain barrier (BBB). We have previously shown that high-amplitude repetitive transcranial magnetic stimulation (rTMS) in rats allowed the delivery across the BBB of an IGF signaling inhibitor-IGF-Trap.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Department of Materials Science and Technology, Tokyo University of Science, 6-3-1, Niijuku Katsushika-ku, Tokyo 125-8585, Japan.
Accurately predicting fatigue failure in CFRP laminates requires an understanding of the cyclic behavior of their resin matrix, which plays a crucial role in the materials' overall performance. This study focuses on the temperature elevation during the cyclic loadings of the resin, driven by inelastic deformations that increase the dissipated energy. At low loading frequencies, the dissipated energy is effectively released as heat, preventing significant temperature rise and maintaining a consistent, balanced thermal state.
View Article and Find Full Text PDFLife (Basel)
December 2024
Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized larval zebrafish model of endotoxicity/sepsis to screen commercial libraries of drugs approved by the U.
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