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The impact of fluticasone furoate/vilanterol on healthcare resource utilisation in the Salford Lung Study in chronic obstructive pulmonary disease. | LitMetric
Aim : The Salford Lung Study (SLS) in chronic obstructive pulmonary disease (COPD) was a randomised controlled trial evaluating the effectiveness and safety of initiating fluticasone furoate/vilanterol (FF/VI) 100/25 µg continuing usual care (UC) in patients with COPD and a history of exacerbations. Here, we investigate the impact of initiating FF/VI on healthcare resource utilisation (HRU) in SLS COPD.Methods : HRU and interventions were determined from patients' electronic health records. Annual rates of on-treatment all-cause and COPD-related secondary care contacts (SCCs) and primary care contacts (PCCs) for FF/VI UC were analysed using a general linear model. Costs were derived from national data sources.Results : Least-squares (LS) mean annual rates of all-cause (9.81 9.36) and COPD-related (1.57 1.48) SCCs were similar for FF/VI and UC, as were rates of all-cause hospitalisations (0.87 0.82). Mean duration of hospital stay/patient was 4.5 and 4.2 days, respectively. COPD-related SCC mean total cost/patient was £484 FF/VI and £475 UC. LS mean annual rates of all-cause PCCs were significantly higher for FF/VI (21.20 18.88 UC; < 0.001). LS mean annual rates of COPD-related PCCs were similar for FF/VI and UC (2.42 2.46). All-cause PCC mean total cost/patient was £900 FF/VI £811 UC, but COPD-related PCC costs were similar (£116 £114). Direct COPD-related total medical costs/patient were significantly lower for FF/VI (LS geometric mean £806 £963 UC; < 0.001).Discussion : In patients with COPD and exacerbation history, FF/VI may represent a less costly alternative to current therapies.GlaxoSmithKline plc. study HZC115151; ClinicalTrials.gov NCT01551758.
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