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| http://dx.doi.org/10.1007/s12928-021-00772-9 | DOI Listing |
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Z-DNA at the crossroads: untangling its role in genome dynamics.
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Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiyacho, Sakyo-Ku, Kyoto 606-8501, Japan. Electronic address:
DNA can fold into noncanonical left-handed Z-DNA conformation beyond the right-handed B-DNA. While its crystal structure was discovered nearly four decades ago, it was predominantly considered a structural curiosity. Recent evidence suggests that Z-DNA formation occurs in nuclear and mitochondrial DNA (mtDNA), with significant biological implications.
View Article and Find Full Text PDFThe inclusion and consideration of cultural differences and health inequalities in physical activity behaviour in the UK - the impact of guidelines and initiatives.
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Healthy Living for Pandemic Event Protection Network (HL-Pivot), UK; Research Centre for Physical Activity, Sport and Exercise Science, Coventry University, UK.
Despite widespread attempts from governments and leading health organisations worldwide to promote equity in healthy living medicine, the evidence suggests that attempts to curb worsening public health have been almost entirely ineffective. Despite significant advancements in knowledge, medicine, and technology, as well as the promotion of guidelines and the implementation of numerous global initiatives aimed at addressing health disparities and mitigating the progression of non-communicable diseases (NCDs) worldwide, substantial work remains to be undertaken particularly in addressing inequalities in physical activity. Achieving equitable access to health resources and parity in health outcomes remains a critical and unresolved challenge.
View Article and Find Full Text PDFInvestigating Past, Present, and Future Trends on Interface Between Marine and Medical Research and Development: A Bibliometric Review.
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Kiel Institute for Responsible Innovation, Chair of Technology Management, Kiel University (Christian-Albrechts-Universität zu Kiel), 24118 Kiel, Germany.
The convergence of marine sciences and medical studies has the potential for substantial advances in healthcare. This study uses bibliometric and topic modeling studies to map the progression of research themes from 2000 to 2023, with an emphasis on the interdisciplinary subject of marine and medical sciences. Building on the global publication output at the interface between marine and medical sciences and using the Hierarchical Dirichlet Process, we discovered dominating research topics during three periods, emphasizing shifts in research focus and development trends.
View Article and Find Full Text PDFRetraction Note: Navigating the crossroads: cardiometabolic risks in cancer survivorship - a comprehensive review.
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Biocomputing at the crossroad between emulating artificial intelligence and cellular supremacy.
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Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Medicine and School of Life Sciences, Westlake University, 310024 Hangzhou, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, 310024 Hangzhou, Zhejiang, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 310024 Hangzhou, Zhejiang, China; School of Engineering, Westlake University, 310030 Hangzhou, Zhejiang, China. Electronic address:
Biocomputation aims to create sophisticated biological systems capable of addressing important problems in (bio)medicine with a machine-like precision. At present, computational gene networks engineered by single- or multi-layered assembly of DNA-, RNA- and protein-level gene switches have allowed bacterial or mammalian cells to perform various regulation logics of interest, including Boolean calculation or neural network-like computing. This review highlights the molecular building blocks, design principles, and computational tasks demonstrated by current biocomputers, before briefly discussing possible fields where biological computers may ultimately outcompete their electronic counterparts and achieve cellular supremacy.
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