AI Article Synopsis
- Disruptions in food intake mechanisms can lead to eating disorders like obesity and anorexia, making it essential to study food motivation and consumption.
- The Feeding Experimentation Device version 3 (FED3) is a new tool that allows researchers to monitor both food intake and the motivation behind it in rodent home-cages, facilitating in-depth studies with less intervention.
- FED3 can also synchronize with optogenetic stimulation or neural recordings and is open-source, allowing researchers to customize the device for their specific research needs.
Article Abstract
Feeding is critical for survival, and disruption in the mechanisms that govern food intake underlies disorders such as obesity and anorexia nervosa. It is important to understand both food intake and food motivation to reveal mechanisms underlying feeding disorders. Operant behavioral testing can be used to measure the motivational component to feeding, but most food intake monitoring systems do not measure operant behavior. Here, we present a new solution for monitoring both food intake and motivation in rodent home-cages: the Feeding Experimentation Device version 3 (FED3). FED3 measures food intake and operant behavior in rodent home-cages, enabling longitudinal studies of feeding behavior with minimal experimenter intervention. It has a programmable output for synchronizing behavior with optogenetic stimulation or neural recordings. Finally, FED3 design files are open-source and freely available, allowing researchers to modify FED3 to suit their needs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075584 | PMC |
| http://dx.doi.org/10.7554/eLife.66173 | DOI Listing |
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