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| http://dx.doi.org/10.1148/rycan.2020209031 | DOI Listing |
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In‐Vivo Characterization of Blood‐Brain Barrier Permeability in Cognitively Normal APOE e4 Carriers and Non‐Carriers.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA
Background: An intact blood‐brain barrier (BBB) is critical for optimal brain health, and even transient or highly localized disruption of the BBB can have devastating consequences for neural functioning. BBB breakdown has been implicated in Alzheimer’s Disease (AD) pathogenesis, and elevated BBB permeability has been observed in APOE e4 carriers compared to non‐carriers. As prior studies have focused on a priori, AD‐vulnerable regions rather than whole‐brain analyses, little is understood about broader patterns of BBB breakdown that may relate to AD risk.
View Article and Find Full Text PDFBlood‐brain barrier breakdown and abnormal brain microstructure in older adults with COVID‐19‐related cognitive impairment are modified by sex and APOE4.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA
Background: Persistent neurological symptoms including cognitive impairment can follow SARS‐CoV‐2 infection, a condition termed neurological post‐acute sequelae of COVID‐19 (Neuro‐PASC). Structural brain differences have been observed in individuals with Neuro‐PASC, raising concern that COVID‐19 may promote age‐related neurodegeneration. However, the mechanisms by which COVID‐19 impairs cognition and its impact on brain aging, remain poorly characterized.
View Article and Find Full Text PDFDynamic contrast enhanced MRI reveals impaired blood brain barrier in basal forebrain region in patients with Alzheimers disease: A pilot study.
Alzheimers Dement
December 2024
Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
Background: Blood brain barrier (BBB) is a protective layer of cells that separates the circulatory system from the brain. Its dysfunction is one of the possible mechanisms leading to onset of Alzheimer's disease (AD), a progressive neurodegenerative disease and a leading cause of dementia worldwide. Dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) is a imaging technique allowing regional assessment of BBB breakdown by estimating local metrics of capillary permeability such as K‐trans (volume transfer constant).
View Article and Find Full Text PDFPresence of Fragmented Intratumoral Thrombosed Microvasculature in the Necrotic and Peri-Necrotic Regions on SWI Differentiates IDH Wild-Type Glioblastoma From IDH Mutant Grade 4 Astrocytoma.
J Magn Reson Imaging
January 2025
Department of Radiology, Fortis Memorial Research Institute, Gurugram, India.
Background: Isocitrate dehydrogenase (IDH) wild-type (IDH) glioblastomas (GB) are more aggressive and have a poorer prognosis than IDH mutant (IDH) tumors, emphasizing the need for accurate preoperative differentiation. However, a distinct imaging biomarker for differentiation mostly lacking. Intratumoral thrombosis has been reported as a histopathological biomarker for GB.
View Article and Find Full Text PDFClinical Efficacy of Ultrafast Dynamic Contrast-Enhanced MRI Using Compressed Sensing in Distinguishing Benign and Malignant Soft-Tissue Tumors.
Korean J Radiol
January 2025
Research Scientist, AIRS Medical Inc., Seoul, Republic of Korea.
Objective: To evaluate the clinical efficacy of ultrafast dynamic contrast-enhanced (DCE)-MRI using a compressed sensing (CS) technique for differentiating benign and malignant soft-tissue tumors (STTs) and to evaluate the factors related to the grading of malignant STTs.
Materials And Methods: A total of 165 patients (96 male; mean age, 61 years), comprising 111 with malignant STTs and 54 with benign STTs according to the 2020 WHO classification, underwent DCE-MRI with CS between June 2018 and June 2023. The clinical, qualitative, and quantitative parameters associated with conventional MRI were also obtained.
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