AI Article Synopsis
- Integrins are key receptors for adhesion and migration, showing varying expression levels in different natural killer (NK) cell subsets depending on their microenvironment.
- Tissue resident NK cells are identified by unique integrin profiles, which help them localize to specific tissue areas and influence their function.
- This review focuses on the different integrin subtypes found on NK cells to clarify how their selection affects tissue residency and overall cell function in various environments.
Article Abstract
Integrins are transmembrane receptors associated with adhesion and migration and are often highly differentially expressed receptors amongst natural killer cell subsets in microenvironments. Tissue resident natural killer cells are frequently defined by their differential integrin expression compared to other NK cell subsets, and integrins can further localize tissue resident NK cells to tissue microenvironments. As such, integrins play important roles in both the phenotypic and functional identity of NK cell subsets. Here we review the expression of integrin subtypes on NK cells and NK cell subsets with the goal of better understanding how integrin selection can dictate tissue residency and mediate function from the nanoscale to the tissue environment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987804 | PMC |
| http://dx.doi.org/10.3389/fimmu.2021.647358 | DOI Listing |
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