Countries disagree on coronavirus vaccination strategies amid warnings that a long time between shots could create lethal variants, says .
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| http://dx.doi.org/10.1016/S0262-4079(21)00440-1 | DOI Listing |
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Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
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Wisconsin Institute for Discovery, Chemical and Biological Engineering, University of Wisconsin-Madison, 330 N. Orchard Street, Madison, WI, 53715, USA. Electronic address:
Single-cell studies of virus infection have found significant heterogeneity in virus and host gene expression as well as the kinetics of progeny particle release. However, such studies have yet to examine how the resulting virus descendants spread and infect nearby cells. We monitored reporter-gene expression from a recombinant rhinovirus in cell monolayers infected at low multiplicity of infection; we found that the second round of infection consistently exhibited a shorter delay in fluorescence signal appearance relative to the first round, indicating an acceleration in infection spread.
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