CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing.

Neurosci Biobehav Rev

Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway; Department of Informatics, University of Oslo, Norway. Electronic address:

Published: July 2021

Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.

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http://dx.doi.org/10.1016/j.neubiorev.2021.03.020DOI Listing

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