[Figure: see text].
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Preeclampsia (PE) is a prevalent and severe pregnancy complication that significantly impacts maternal and perinatal health. Epidemiological studies and animal experiments have demonstrated that PE adversely affects the cardiovascular and nervous systems of offspring, increasing their risk of hypertension and renal pathology. However, the mechanisms underlying this increased risk remain unclear.
View Article and Find Full Text PDFAngiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia.
BMC Pregnancy Childbirth
January 2025
Collection Biologique de L'Hôpital de La Mère Et de L'Enfant CB-HME (Mother and Child Biobank), University Hospital Center, 8 Avenue Dominique Larrey, Limoges, France.
Background: Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers.
Methods: Women with preeclampsia and their neonates were included.
Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels.
Cell Mol Life Sci
December 2024
Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Background And Objectives: Maternal western-style diets that are high in glucose and fat have well-known cardiovascular effects on offspring, yet the combined influence of such diets during pregnancy is relatively less comprehended. This study investigates the impact of maternal high glucose and fat diet (HGF) on vascular constriction in offspring and the underlying mechanisms.
Methods And Results: Pregnant Sprague-Dawley rats were provided with either HGF or control diets.
Impact of SARS-CoV-2 on the male reproductive tract: insights from semen analysis and cryopreservation.
J Assist Reprod Genet
December 2024
Department of Gynecology, Division of Gynecology and Reproductive Medicine, Fertility Center, IRCCS Humanitas Research Hospital, 20089, Rozzano, Milan, Italy.
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, affects multiple organs, including the male reproductive system. While viral infections can harm male fertility through cytokine storms, the effects of SARS-CoV-2 on fertility are still unclear. Thus, this study aimed to examine the persistence of viral RNA and inflammatory responses in semen following SARS-CoV-2 infection and the safety of conventional freezing and vitrification techniques.
View Article and Find Full Text PDFMaternal Hypertension Aggravates Vascular Dysfunction After Injury in Male Adult Offspring Through Transgenerational Transmission of N-Methyladenosine.
Hypertension
December 2024
Department of Cardiology, Southern Medical University, Guangzhou, China. (D.Z., J.X.).
Background: Whether maternal hypertension contributes to the enhanced susceptibility to vascular remodeling in adult offspring through epigenetic mechanisms remains unclear. We aimed to address this gap in the literature using a transgenerational mouse model.
Methods: Gestational hypertension was induced in pregnant mice using chronic angiotensin II infusion.
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