Objective: To compare the usefulness of shock index (SI) and lactate for prediction of 24-hour and 28-day mortality in acute heart failure (AHF) patients.
Study Design: A descriptive study. Place and Duration of the Study: Balikesir University Hospital, Balikesir, Turkey; from February 2019 to August 2020.
Methodology: One hundred and twelve AHF patients presenting to ED were recruited into the study. Usefulness of lactate and SI in predicting mortality at 24-hour and 28-day, was evaluated.
Results: The area under the curve (AUC) was found to be 0.825 for lactate and 0.818 for SI in predicting 24-hour mortality. There was significant difference between the diagnostic performances of 2 markers in predicting 24-hour mortality. AUC was found to be 0.775 for lactate and 0.722 for SI in predicting 28-day mortality. No significant difference was found between the diagnostic performances of the two markers in predicting 28-day mortality. The 24-hour non-survivor rates were found to be 86.67% in patients with lactate levels >2.57; 76.47% in patients with SI >0.94, and 93.33% in patients with lactate levels >2.57 or SI >0.94. The 28-day non-survivor rates were found to be 64.71% in patients with lactate levels >2.57; 70.59% in patients with SI >0.82, and 82.35% in patients with lactate levels >2.57 or SI >0.82.
Conclusion: Lactate level and SI of AHF patients calculated in ED triage may be used to predict mortality, and simultaneous use of both parameters may be more helpful. Key Words: Acute heart failure, Emergency department, Lactate, Mortality, Shock index.
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http://dx.doi.org/10.29271/jcpsp.2021.03.262 | DOI Listing |
Pediatr Nephrol
January 2025
Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong, China.
This case report presents a newborn with pyruvate dehydrogenase complex deficiency who developed significant lactic acidosis and acute kidney injury after birth. Peritoneal dialysis with glucose-based peritoneal dialysis fluid was initially started, but the patient had worsening hyperglycemia and lactic acidosis, likely related to excess glucose reabsorption with shunting to lactate due to the underlying metabolic disorder. As amino acid-based dialysis solution was not available in our formulary, a dialysis fluid was manually created with Vaminolact, which was commonly used in neonatal parenteral nutrition.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Oncology, Suining Central Hospital, Suining, Sichuan, China.
Glioblastoma(GBM) is a highly malignant primary central nervous system tumor that poses a significant threat to patient survival due to its treatment resistance and rapid recurrence.Current treatment options, including maximal safe surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy, have limited efficacy.In recent years, the role of glycolytic metabolic reprogramming in GBM has garnered increasing attention.
View Article and Find Full Text PDFFront Cardiovasc Med
January 2025
Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare type of vasculitis characterized by inflammation within small blood vessels or tissues that may cause damage to the lungs, heart, kidneys, and other organs. Here, we present a rare case of EGPA with cardiac involvement that presented with acute heart failure.
Clinical Findings: A 44-year-old woman with a history of bronchial asthma and sinusitis presented with fever, shortness of breath, fatigue, unintentional weight loss, and polyarthritis.
J Med Biochem
November 2024
The First Affiliated Hospital of Anhui Medical University, Department of Emergency Intensive Care Unit, Hefei, China.
Background: This study investigates the correlation between the difference in hematocrit (HCT) and serum albumin (ALB) levels (HCT-ALB), muscle tissue oxygen saturation (SmtO2), capillary refill time (CRT), and blood lactate (Lac) with the severity of renal function damage and prognosis in patients with septic shock.
Methods: Conducted from February 2022 to February 2024, this study included 116 septic shock patients treated at the First Affiliated Hospital of Anhui Medical University. Patients were divided into groups based on whether they developed acute kidney injury: 40 patients were included in the acute kidney injury group, and the remaining 76 were placed in the non-kidney injury group.
Front Cell Neurosci
January 2025
Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Protein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have been linked to protein lactylation in brain tissue, which has been shown to correlate with increased neuronal excitability. Ischemic stroke may promote neuronal glycolysis, leading to lactate accumulation in brain tissue.
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