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| http://dx.doi.org/10.1016/j.jinf.2021.03.017 | DOI Listing |
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Advances in Whole Genome Sequencing: Methods, Tools, and Applications in Population Genomics.
Int J Mol Sci
January 2025
Yunnan Provincial Key Laboratory of Animal Nutrition and Feed, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
With the rapid advancement of high-throughput sequencing technologies, whole genome sequencing (WGS) has emerged as a crucial tool for studying genetic variation and population structure. Utilizing population genomics tools to analyze resequencing data allows for the effective integration of selection signals with population history, precise estimation of effective population size, historical population trends, and structural insights, along with the identification of specific genetic loci and variations. This paper reviews current whole genome sequencing technologies, detailing primary research methods, relevant software, and their advantages and limitations within population genomics.
View Article and Find Full Text PDFApplication of Biofire Filmarray Joint Infection Panel for Rapid Identification of Aetiology in a Necrotizing Fasciitis Case.
Diagnostics (Basel)
December 2024
Medical Microbiology, Clinical Center, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
: Monomicrobial necrotizing fasciitis is associated with exceedingly high mortality rates. Although effective antimicrobial therapy is an important part of treatment, the traditional microbiological diagnostic methods are not fast enough to meaningfully influence early therapeutic decisions. : Here, we report the application of the BioMérieux Biofire Filmarray Joint Infection Panel (BFJIP) for the rapid detection of the causative agent and susceptibility prediction in such a case.
View Article and Find Full Text PDFGenetic Characteristics of the Rat Fibroblast Cell Line Rat-1.
Cells
December 2024
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH, University Hospital Aachen, D-52074 Aachen, Germany.
The Rat-1 cell line was established as a subclone of the parental rat fibroblastoid line F2408, derived from Fisher 344 rat embryos. Rat-1 cells are widely used in various research fields, especially in cancer biology, to study the effects of oncogenes on cell proliferation. They are also crucial for investigating signal transduction pathways and play a key role in drug testing and pharmacological studies due to their rapid proliferation.
View Article and Find Full Text PDFComplete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018.
Heliyon
March 2024
Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh.
Foot-and-mouth disease virus (FMDV), the causative agent of the foot-and-mouth disease of cattle population possesses a rapid evolutionary rate. In Bangladesh, the first circulation of the O/ME-SA/SA-2018 lineage as a novel sublineage, MYMBD21 was reported from our laboratory. The first whole genome sequence of an isolate, BAN/MY/My-466/2021 (shortly named My-466) of the SA-2018 lineage is characterized and represented in this study.
View Article and Find Full Text PDFThe pathway alteration load is a pan-cancer determinant of outcome of targeted therapies: results from the Drug Rediscovery Protocol (DRUP).
ESMO Open
January 2025
Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Oncode Institute, Utrecht, The Netherlands. Electronic address:
Background: Many patients with cancer exhibit primary or rapid secondary resistance to targeted therapy (TT). We hypothesized that a higher number of altered oncogenic signaling pathways [pathway alteration load (PAL)] would reduce the benefit of TT which only intervenes in one pathway. This hypothesis was tested in the Drug Rediscovery Protocol (DRUP).
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