Ellagic acid solid dispersion (EASD) was prepared using polyvinylpyrrolidone (PVP) as a carrier to improve its solubility. The solubility of EASD enhanced to 0.593 mg/mL, more than 20 times of the solubility on pure EA. The structure of EASD was analyzed by UV-visible spectroscopy, Fourier transforms infrared spectrometer (FT-IR) and X-ray diffraction (XRD), and results indicated the successful preparation of EASD, with a decrease in crystallinity. Differential scanning calorimetry (DSC) spectrums showed a lower endothermic peak of EASD than EA. By antioxidant analysis, the EASD with the concentration of 3 mg/mL was used in the protein oxidation analysis in hydroxyl radical oxidation simulation system, which was established by the myofibrillar of hairtail. EASD exhibited an excellent inhibit effect on protein oxidation. By increasing the solubility, EASD broadens the application range of EA, providing a theoretical basis for its application in the preservation of aquatic products.
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