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Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw.
J Dent Res
December 2024
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Both the upper and lower jaws develop from cranial neural crest cells (CNCCs) populating the first pharyngeal arch in all gnathostomes. Previous studies showed that the Edn1/Ednra-Dlx5/Dlx6-Hand2 signaling pathway is necessary for lower jaw formation and that ectopic expression of or throughout the CNCCs partly transformed the upper jaw to lower jaw structures, but the molecular mechanisms regulating upper jaw development remain unclear. Here we show that the basic helix-loop-helix transcription factor Twist1 is required for upper jaw development.
View Article and Find Full Text PDFImpacted supernumerary tooth in the horizontal plate of palatine bone: a rare case report.
BMC Oral Health
December 2024
Nepalese Army Institute of Health Sciences, College of Medicine, Kathmandu, Nepal.
Background: Supernumerary teeth, defined as extra teeth beyond the normal series of dentition, can appear anywhere in the dental arch. They may present as solitary or multiple, unilateral or bilateral, and can be either erupted or impacted. Rarely, supernumerary teeth are found in ectopic locations outside the dental arches, such as the nasal cavity, inferior nasal conchae, maxillary sinus, ethmoid sinus, or skull.
View Article and Find Full Text PDFOperational Distal Shoe Appliance for Harmonious Occlusion: A Case Report.
Int J Clin Pediatr Dent
October 2024
Department of Pediatric and Prevntive Dentistry, Kalinga Institute of Dental Sciences, KIIT (Deemed to be University), Bhubaneswar, Odisha, India.
Unlabelled: Preserving deciduous teeth till their natural exfoliation is important to maintain arch length in different dentition periods. Premature loss of primary teeth may cause discrepancy in arch length due to drifting of teeth and supraeruption of the opposite teeth, thereby hindering the development of a harmonious, functionally and esthetically acceptable dentition. This article describes the fabrication and clinical application of a modified functional distal shoe appliance used due to pathological obliteration of the primary/deciduous mandibular second molar prior to the eruption of the permanent mandibular first molar.
View Article and Find Full Text PDFAn unexpected variation of occipital and ascending pharyngeal arteries: clinical implications.
Surg Radiol Anat
November 2024
Creighton University School of Medicine-Phoenix Regional Campus, Phoenix, AZ, USA.
Article Synopsis
- The study focuses on the anatomy of the External Carotid Artery (ECA) and identifies a rare variant where the Occipital Artery (OA) and Ascending Pharyngeal Artery (APA) originate from the Internal Carotid Artery (ICA) instead of the typical ECA branches.
- Dissection of 28 formaldehyde donors revealed this variation in one case, specifically on the right side, with a notable bifurcation angle of nearly 180 degrees.
- The findings highlight the importance of recognizing this variation for surgeons and radiologists, improving procedural planning and reducing complications in head and neck surgeries.
Distalization of Ectopically Erupted Molars Using a Modified Humphrey's Appliance.
Front Dent
August 2024
Department of Pediatric Dentistry, ESIC Dental College and Hospital, Rohini, New Delhi, India.
Ectopic eruption of molars occurs more frequently in developing permanent dentition, and requires immediate intervention. Herein, two cases are discussed with ectopic eruption of permanent maxillary first molars which were diagnosed and managed conservatively using a modified Humphrey's appliance, named the NR's appliance. The appliance was fabricated by band adaptation and using wire components of a 21-gauge stainless-steel wire.
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