-. Single-spanning SARS-CoV-2 envelope (E) protein topology is a major determinant of protein quaternary structure and function. -. Charged residues distribution in E protein sequences from highly pathogenic human coronaviruses (, SARS-CoV, MERS-CoV and SARS-CoV-2) stabilize Nt-Ct membrane topology. -. E protein sequence could have evolved to ensure a more robust membrane topology from MERS-CoV to SARS-CoV and SARS-CoV-2.
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| http://dx.doi.org/10.1016/j.bbamem.2021.183608 | DOI Listing |
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