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  • * Melanocytes were successfully purified and cultured from ovarian tissues using a collagenase and trypsin-EDTA mixture, and RNA sequencing analysis was performed to compare gene expression in ovarian vs. peritoneal melanocytes.
  • * Results showed that ovarian melanocytes express higher levels of genes linked to sexual hormone production and melanogenesis, while peritoneal melanocytes are more involved in metabolic processes, suggesting the function of melanocytes varies by tissue origin and developmental stage.
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A 29-year-old female, with giant congenital melanocytic naevi (GCMN) presented with a-year history of symptoms and signs of intracranial hypertension. Investigations revealed raised cerebrospinal fluid (CSF) pressure and severe hypoglycorrhachia (low CSF glucose) without pleocytosis. Initial contrast-enhanced brain MRI was normal, but a repeat MRI after a year showed meningeal enhancement with mild communicating hydrocephalus.

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Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis.

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Department of Neurosurgery, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, 951-8585, Niigata, Japan.

Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by congenital melanocytic nevus of skin and abnormal proliferation of leptomeningeal melanocytes. Early acquisition of post-zygotic somatic mutations has been postulated to underlie the pathogenesis of NCM. The pathogenesis of NCM remains to be fully elucidated, and treatment options have not been established.

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