Wideband signal generation using frequency/phase modulation (FM/PM) is the key fundamental function for various applications such as radar and analog communication systems. It is well known that analog FM/PM communication systems can dramatically improve signal quality by spectral expansion. In classical communication theories, the Armstrong indirect method is one of the most popular methods for bandwidth expansion of FM signals. In the Armstrong method, a narrowband signal is converted to a broadband signal with the help of a nonlinear frequency multiplier. In this paper, we propose a photonic Armstrong method enabled by direct detection. By utilizing the nonlinearity caused by direct detection, we can increase bandwidth so that it is double that of the original signal in the photonic Armstrong method. Also, it completely eliminates signal-to-signal beat interference (SSBI) at the same time. We conducted an experiment to verify the concept and confirmed these advantages experimentally.
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http://dx.doi.org/10.1364/OE.417640 | DOI Listing |
J Clin Oncol
January 2025
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
Purpose: Melanoma as a subsequent malignant neoplasm has been described among childhood cancer survivors; however, the risk factors and long-term survival are not well understood.
Methods: We assessed incidence, risk factors, and outcomes for melanoma among participants in the Childhood Cancer Survivor Study cohort. Cumulative incidence and standardized incidence ratios (SIRs) were calculated, and multivariable Cox models were used to determine hazard ratios (HRs) and associated 95% CI for melanoma risk factors.
Diabetology (Basel)
October 2024
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Objectives: This study aims to examine the association between state Medicaid coverage of podiatry services and the outcomes of beneficiaries with new diabetic foot ulcers (DFUs).
Methods: Medicaid beneficiaries who developed a DFU between 2010 and 2015 were identified using the PearlDiver claims database. The states were categorized into covered states (CS) and non-covered states (NCS) based on podiatric coverage during the study period.
Introduction: This scoping review examines the application and evolution of the Social-Ecological Model for Adolescent and Young Adult Readiness for Transition (SMART). SMART provides a framework for assessing transition readiness across pediatric chronic conditions. Evaluating its research and clinical applications identifies insights and gaps across conditions and stakeholders.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2025
Keck School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
Background: Lebrikizumab monotherapy significantly improved signs and symptoms in patients with moderate-to-severe atopic dermatitis (AD) in phase 3 Advocate1 and ADvocate2 studies.
Objective: To evaluate improvements in patient-reported symptoms and quality-of-life (QoL) measures by Eczema Area and Severity Index (EASI) response categories using pooled Advocate1 and ADvocate2 data (post hoc analysis).
Methods: In the 52-week (W) (16-W induction + 36-W maintenance) double-blind, placebo-controlled ADvocate1 and ADvocate2 studies, patients were randomized (2:1) to receive subcutaneous lebrikizumab 250 mg or placebo every 2 weeks.
Rep Pract Oncol Radiother
December 2024
Radiation Oncology, St Luke's Hospital, Network, Dublin, Ireland.
Background: The onset of the coronavirus disease 2019 (COVID-19) outbreak caused major interruptions to the entire healthcare network affecting referral, diagnosis and treatment pathways with the potential to affect cancer treatment outcomes. In Ireland a national lockdown was initiated in March 2020 involving a stay-at-home order with a limitation on travel, social interactions and closure of schools, universities and childcare facilities. We designed a retrospective study comparing treatment outcomes for patients with oropharyngeal cancer treated before and during the COVID pandemic.
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