AI Article Synopsis
- A new method for creating α-hydroxy ketones is introduced, which involves a cross-coupling reaction between aromatic aldehydes and arylnitriles.
- This reaction uses a copper catalyst and silylboronate as a reducing agent, showcasing a unique approach to chemoselectivity.
- The technique represents a novel way of accomplishing electrophile-electrophile cross-coupling in organic synthesis.
Article Abstract
A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of α-hydroxy ketones by electrophile-electrophile cross-coupling.
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| http://dx.doi.org/10.1002/chem.202100763 | DOI Listing |
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