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Preclinical evaluation of the efficacy and safety of AAV8-TNAP-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia.
J Bone Miner Res
January 2025
Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP), with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4x108 up to 4x1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4x106 up to 4x109 (vg/b) was administered to 8-week-old AlplPrx1/Prx1 mice (a late-onset HPP model).
View Article and Find Full Text PDFImproving spleen segmentation in ultrasound images using a hybrid deep learning framework.
Sci Rep
January 2025
School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
This paper introduces a novel method for spleen segmentation in ultrasound images, using a two-phase training approach. In the first phase, the SegFormerB0 network is trained to provide an initial segmentation. In the second phase, the network is further refined using the Pix2Pix structure, which enhances attention to details and corrects any erroneous or additional segments in the output.
View Article and Find Full Text PDFNeural processing of auditory stimuli in rats: translational aspects using auditory oddball paradigms.
Behav Brain Res
January 2025
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; Cluster of Excellence Hearing4all, German Research Foundation, Hannover, Germany; Center for Systems Neuroscience (ZSN) Hannover, 30559 Hannover, Germany.
Background: The three-class oddball paradigm allows to investigate the processing of behaviorally relevant and irrelevant auditory stimuli. In humans, event-related potentials (ERPs) are used as neural correlate of behavior. We recorded local field potentials (LFPs) within the medial prefrontal cortex (mPFC) in rats during three-class and passive two-class oddball paradigms and analyzed the ERPs focusing on similarities to human recordings.
View Article and Find Full Text PDFFocal volume reduction in transcranial focused ultrasound using spherical wave expansions.
Ultrasonics
January 2025
School of Biological Science and Medical Engineering, Beihang University, Beijing, China. Electronic address:
Transcranial focused ultrasound (tFUS) has been gaining increased attention as a non-invasive modality for treating brain diseases. However, accurately focusing on brain structures remains a challenge as the ultrasound is severely distorted by the presence of the skull. In this article, we propose a promising distortion correction method based on spherical wave expansions.
View Article and Find Full Text PDFTranslating and culturally adapting the sleep disturbance scale for children into Malayalam language: Enhancing pediatric health in the Indian context.
J Indian Soc Pedod Prev Dent
October 2024
Department of Pediatric and Preventive Dentistry, PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India.
Purpose: The sleep disturbance scale for children (SDSC) is a well-regarded tool for assessing pediatric sleep disorders, covering areas such as sleep initiation, breathing issues, and arousal disorders. The SDSC, known for its reliability and validity, has been adapted for various age groups and languages and aligns with the Association of Sleep Disorders Centers classification system. This study aimed to translate and culturally adapt the SDSC into Malayalam language for use in Kerala, conducting a test with parents from the Trivandrum district.
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