Patients with soft tissue sarcomas should be assessed for neurotrophic tropomyosin receptor kinase (NTRK) gene fusions as neoadjuvant treatment with larotrectinib may prevent amputation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981750PMC
http://dx.doi.org/10.1002/ccr3.3878DOI Listing

Publication Analysis

Top Keywords

soft tissue
8
larotrectinib ntrk-rearranged
4
ntrk-rearranged soft
4
tissue sarcoma
4
sarcoma neoadjuvant
4
neoadjuvant setting
4
setting case
4
case report
4
report patients
4
patients soft
4

Similar Publications

Background: Soft-tissue sarcoma involving the popliteal fossa remains challenging because it is difficult to achieve wide margins with limb salvage in this location. Adjuvant therapy is frequently necessary, and limb function can be adversely affected. We reviewed our experience with these tumors.

View Article and Find Full Text PDF

Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review.

Indian J Orthop

January 2025

Department of Orthopedics, Hand, and Reconstructive Microsurgery, Olympia Hospital & Research Centre, 47, 47A Puthur High Road, Puthur, Trichy, Tamilnadu 620017 India.

Background: Musculoskeletal ultrasonography of the hand and wrist is becoming the trend in assessing and diagnosing most hand and wrist injuries, soft-tissue mass, and occult fractures. Its advantages include ultra-high frequency probes, noninvasiveness, cost-effectiveness, lack of ionising radiation, and portability. The patients are comfortable doing this procedure in the outpatient department, and visualising the ultrasound images increases their confidence.

View Article and Find Full Text PDF

Sinonasal leiomyoma is an exceptionally rare neoplasm arising from smooth muscle cells within the sinonasal tract. This abstract presents a case study of a 43-year-old male patient diagnosed with sinonasal leiomyoma, a distinctive and challenging entity in otolaryngology. The patient presented with a complex clinical history, including a 2-year interval between initial evaluation and definitive diagnosis.

View Article and Find Full Text PDF

The scarring stage of noma disease often presents with composite tissue loss involving hard and soft tissues with resultant fibrosis making reconstruction a challenge. Microvascular reconstruction option is associated with good outcomes when the expertise is available. Trismus, which is caused by either soft tissue fibrosis or the union of the coronoid to the zygomatic complex, is also a common presentation.

View Article and Find Full Text PDF

Background: Necrotizing fasciitis (NF) is a severe soft tissue infection typified by swiftly spreading necrosis of the fascia and subcutaneous fat with successive necrosis of the skin which affects all age groups.

Objective: To compare the clinical presentation and treatment outcome of NF between children and adults.

Materials And Methods: A prospective descriptive study of all patients presenting with NF to the (Usmanu Danfodiyo Univrersity Teaching Hospital, Sokoto), from September 2018 to August 2019.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!