Objectives: To investigate whether 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) can improve the diagnostic performance of TNM staging and help in making an accurate decision regarding resectability in patients with recurrent gastric cancer compared to multi-detector computed tomography (MDCT).
Methods: Fifty patients with histologically (n = 31) or clinically (n = 19) confirmed recurrent gastric cancer underwent both MDCT and [F]FDG PET/MRI. Two radiologists independently assessed TNM staging using MDCT with and without [F]FDG PET/MRI and scored resectability using a 5-point confidence scale. Diagnostic performance as assessed by radiologists was compared using McNemar's test and receiver operating characteristic curve analysis.
Results: Of the 50 patients, pathologic T and N staging was available in seven and six patients, respectively. Diagnostic accuracies for T and N staging were not significantly different between MDCT with and without [F]FDG PET/MRI for both reviewers (p > 0.05). However, for M staging, diagnostic accuracy was significantly improved when F-FDG PET/MRI was added to MDCT alone (68.0% [34/50] to 90.0% [45/50] for reviewer 1 [p = 0.001] and 66.0% [33/50] to 96.0% [46/50] for reviewer 2 [p < 0.001]). Regarding the resectability of recurrent gastric cancers, the addition of [F]FDG PET/MRI increased the area under the curve values for both reviewers (from 0.860 to 0.989 for reviewer 1 and from 0.778 to 0.898 for reviewer 2), with a statistical significance for reviewer 2 (p = 0.002).
Conclusion: Compared to MDCT alone, MDCT plus [F]FDG PET/MRI can improve the diagnostic accuracy for evaluating preoperative M staging as well as resectability for recurrent gastric cancers.
Key Points: • [F]FDG PET/MRI can improve diagnostic accuracy for preoperative M staging in patients with recurrent gastric cancers. • [F]FDG PET/MRI can improve diagnostic accuracy for determining resectability in patients with recurrent gastric cancers. • [F]FDG PET/MRI can provide critical clues for management options for recurrent gastric cancers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00330-021-07839-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Detection of Crossed Cerebellar Diaschisis in Intractable Epilepsy Using Integrated F-FDG PET/MR Imaging.
Cerebellum
December 2024
Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.
Crossed cerebellar diaschisis(CCD) involves reduced metabolism and blood flow in the cerebellar hemisphere contralateral to a supratentorial lesion. ASL is a valuable tool for quantifying regional cerebral blood flow. This study assesses ASL-MRI's ability to detect CCD in epilepsy using integrated F-FDG PET/MRI and compares ASL with PET images in evaluating CCD.
View Article and Find Full Text PDFDynamic 18 F-FDG PET to detect differences among patients with progressive and relapsing multiple sclerosis: a pilot study.
Neurol Sci
December 2024
Neuroimmunology Unit, La Fe University and Polytechnic Hospital, Avda. Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Background: Patients with multiple sclerosis (MS) may remain in a relapsing-remitting (RRMS) course despite long-standing disease, while others will develop secondary progression (SPMS). Chronic inflammation and changes in the blood-brain barrier resulting in perturbed glucose metabolism may account for these differences. PET-MRI with kinetic analysis of 2-deoxy-2(18 F)fluoro-d-glucose (18 F-FDG) provides insight into glucose metabolism and has proven useful in several chronic inflammatory diseases.
View Article and Find Full Text PDFBrain development during the lifespan of cynomolgus monkeys.
Neuroimage
December 2024
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510632, China. Electronic address:
Article Synopsis
- - The study addresses the lack of suitable brain templates for cynomolgus monkeys in neuroscience research, highlighting the need for better tools to analyze neuroimaging data due to age-related changes in brain structure and function.
- - To improve data analysis accuracy, a comprehensive set of stereotaxic brain templates has been developed, which includes various MRI and PET templates for different stages of development in cynomolgus monkeys.
- - These new templates allow for precise localization and segmentation of brain structures, enabling more reliable studies of brain anatomy and metabolic function in non-human primates.
First-in-human Evaluation of Safety and Dosimetry of [Cu]FBP8: A fibrin-binding PET Probe.
Mol Imaging Biol
December 2024
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
Article Synopsis
- - The study investigates the safe use and distribution of a new imaging probe called [Cu]Fibrin Binding Probe #8 ([Cu]FBP8) in healthy individuals, focusing on its potential for thrombus imaging and pulmonary fibrosis detection.
- - Eight participants underwent PET/MRI sessions after receiving the probe, which showed quick blood clearance and renal excretion, with the urinary bladder and kidneys receiving the highest radiation doses.
- - Findings suggest that [Cu]FBP8 has low dosimetry, rapid clearance, and low background signal, making it a promising tool for non-invasive imaging in various medical conditions related to cardiovascular, cancer, and neurological issues.
Author Correction: Integration of whole-body [F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes.
Sci Rep
November 2024
Department of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!