AI Article Synopsis
- The study assesses the long-term durability of the immune response to SARS-CoV-2 about six months after infection, focusing on memory B cells and T cells.
- Memory B cells specific to the virus's spike protein were found in low numbers in recovered individuals, particularly in those who had asymptomatic cases.
- T cell responses were observed in both recovered COVID-19 patients and some healthy individuals, indicating potential cross-reactive immunity.
Article Abstract
It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993859 | PMC |
| http://dx.doi.org/10.1038/s41421-021-00250-9 | DOI Listing |
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