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Interactive Association of XRCC1, XRCC2, XRCC3, and TP53 Gene Polymorphisms With Gastrointestinal Cancer Risk: Insights From a Hospital-Based Case-Control Study.
Cureus
June 2024
Department of Oncology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Background And Aim: Gastrointestinal (GI) cancer presents a significant worldwide health burden, influenced by a combination of genetic and environmental factors. This study endeavors to explore the combined effects of the , , , and genes that contribute to the heightened risk of GI cancer, shedding light on their combined influence on cancer susceptibility.
Materials And Methods: A total of 200 histologically confirmed cases of GI cancer and an equal number of controls were selected to examine genetic polymorphisms within the , , , and genes using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
Multi-index comprehensive evaluation of the efficacy and response mechanism of immunotherapy in non-small cell lung cancer.
Clin Transl Oncol
December 2024
Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, China.
Objective: This research conducted multi-index comprehensive evaluations of the immunotherapeutic efficacy and response in non-small cell lung cancer (NSCLC).
Methods: Forty-five patients with epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) wild-type advanced NSCLC who received immunotherapy were included. Immunohistochemistry was adopted to detect the expression levels of programmed death ligand 1 (PD-L1) with X-ray cross-complementing protein 1 (XRCC1) and excision repair cross-complementing group 1 (ERCC1) proteins in tumor tissues.
Genetic and biochemical studies of hepatic carcinoma in the Egyptian population.
J Res Med Sci
August 2021
Department of Biochemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
Background: Hepatocellular carcinoma (HCC), a deadly malignancy of the liver, is considered the third leading reason behind cancer deaths. It is more frequent in men than in women of ages above 50. Liver disease, leading to liver cirrhosis (LC), is mostly caused by alcoholism abuse, reaction diseases of the liver, or viral hepatitis B or C infection.
View Article and Find Full Text PDFInfluence of Arg399Gln, Arg280His and Arg194Trp XRCC1 gene polymorphisms of Base Excision Repair pathway on the level of 8-oxo-guanine and risk of head and neck cancer in the Polish population.
Cancer Biomark
February 2022
Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Łodz, Poland.
Background: Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer.
Objective: In this work we investigate influence of three selected polymorphisms of DNA repair gene XRCC1 and level of oxidative damage (measured as level of 8-oxo-guanine) on modulation of the risk of HNSCC.
Methods: In group of 359 patients with HNSCC (diagnosed with OSCC) the occurrence of polymorphic variants in Arg399Gln, Arg280His and Arg194Trp of XRCC1 were studied with TaqMan technique.
Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis.
Biomed Environ Sci
March 2021
The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao 266000, Shandong, China;Endocrine Genetics Laboratory, Research Institute of the McGill University Health Centre, Montreal H4A 3J1, QC, Canada;Zhejiang MaiDaGene Technology Co., Ltd., Zhoushan 316100, Zhejiang, China.
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