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Clinical Evaluation of the Heparin Therapeutic Window Using Activated Clotting Time in Neurological Interventional Radiology at an Academic Medical Center.
Arch Pathol Lab Med
March 2025
From the Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City (Nelson, Dasgupta, Zheng).
Context.—: Activated clotting time (ACT) is useful for monitoring heparin therapy in neurointerventional radiology (NIR). We previously used the Hemochron Signature Elite instrument for measuring ACT in NIR.
View Article and Find Full Text PDFEffectiveness of different anticoagulation regimens in critically ill patients - experience from COVID 19 patients.
Blood Coagul Fibrinolysis
March 2025
Clinic for Anesthesiology and Intensive Care, Military Medical Academy.
This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy in some cases, we hypothesised that anti-Xa measurement improves anticoagulation effectiveness and clinical outcomes in this population.
View Article and Find Full Text PDFThromboelastometry and two activated clotting tests in detecting residual heparin after protamine in cardiac surgical patients: A prospective cohort study.
Eur J Anaesthesiol
February 2025
From the Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu (JM, MP, PO, TK, PT, TE), Department of Anesthesiology, Vaasa Central Hospital, Wellbeing Services County of Ostrobothnia, Vaasa (MP), Translational Medicine Research Unit, University of Oulu (PO) and Nordlab Oulu Hematology Laboratory, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland (E-RS).
Background: After cardiac surgery, complete heparin reversal with protamine is essential. Accordingly, there is a need for an accurate and precise point-of-care device to detect possible residual heparin after protamine administration.
Objectives: To compare two different activated clotting time (ACT) tests and thromboelastometry in detecting postprotamine heparin activity after cardiac surgery.
Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance.
Front Immunol
February 2025
Unidad de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Factor H (FH) is a crucial complement regulator that prevents complement-mediated injury to healthy cells and tissues. This regulatory function can be disrupted by Factor H autoantibodies (FHAA), which then leads to diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 Glomerulopathy (C3G). In pediatric aHUS, the FHAA incidence is ~10-15%, although in the Indian population, it rises to ~50%.
View Article and Find Full Text PDFInadequate Anti-Factor Xa Levels With Daily 40-mg Enoxaparin After Cardiac Surgery.
Ann Thorac Surg Short Rep
September 2024
Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.
Background: Cardiac surgery patients are at increased risk for venous thromboembolism (VTE). Prevention is the most critical strategy to reduce VTE-associated morbidity and death. However, there is a lack of data on the optimal approach to VTE prophylaxis in this population of high-risk patients.
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