Background: Anticoagulant therapy is indicated for the prevention and treatment of thromboembolic disease. Direct oral anticoagulants (DOACs) are frequently prescribed and Rivaroxaban is the most frequently administered DOAC in the Netherlands. Most side effects relate to hemorrhagic complications, however, also non-hemorrhagic side effect may be potentially life threatening.
Case Presentation: A 74-year-old man presented at the emergency department with a ruptured infrarenal abdominal aortic aneurysm for which open aneurysm repair was performed. Postoperatively, the patient developed neurological deficit, respiratory and circulatory failure following rivaroxaban administration, initiated for atrial fibrillation. Even though, the clinical signs resembled an anaphylactic reaction, the skin-prick test was negative and complications most likely resulted from a non-allergic drug hypersensitivity reaction.
Conclusion: This case report shows that non-allergic drug hypersensitivity reactions may mimic an anaphylactic reaction and can be potentially life threatening. In addition, severe non-hemorrhagic complications after rivaroxaban administration do occur and should be considered in case of acute clinical deterioration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/15385744211004763 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis.
Clin Rev Allergy Immunol
December 2024
Southern Medical University, Guangzhou, China.
Article Synopsis
- * A systematic review and meta-analysis assessed nine studies on capsaicin's effects, finding significant improvements in nasal symptom scores and a higher rate of therapeutic responders compared to placebo.
- * Despite promising results, the review highlights the need for more comprehensive and well-designed clinical trials to better understand capsaicin's role in treating NAR, due to the limited studies and varying methodologies.
Tryptase: The Silent Witness of Past and Ongoing Systemic Events.
Medicina (Kaunas)
August 2024
Clinic of Allergology and Immunology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Article Synopsis
- Tryptase is a key biomarker for diagnosing severe allergic reactions like anaphylaxis and is also important in assessing other mast cell-related conditions.
- The paper highlights two clinical cases to demonstrate the significance of timely measuring serum tryptase during hypersensitivity reactions and emphasizes its broader clinical uses.
- A detailed literature review identified crucial guidelines for interpreting serum tryptase levels, suggesting that elevated levels indicate a higher risk for severe reactions and necessitate further investigation and management.
A comparison of the impact of anti-IL5/5r therapies in allergic versus non-allergic patients with severe eosinophilic asthma in a real-life setting.
J Asthma
February 2025
Department of Allergy, La Paz University Hospital, Madrid, Spain.
Objective: This study aimed to compare the clinical characteristics and treatment outcomes of allergic patients (AP) and non-allergic patients (NAP) with severe eosinophilic asthma (SEA) treated with anti-IL5/IL5R biologic agents (mepolizumab, benralizumab, or reslizumab) over one year. Sub-analyses assessed treatment response variations between AP and NAP based on the biological used and compared outcomes among AP with and without fungal allergy.
Methods: Observational retrospective analysis.
Local Allergic Rhinitis-A Challenge for Allergology and Otorhinolaryngology Cooperation (Scoping Review).
Life (Basel)
July 2024
ENT Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Local allergic rhinitis (LAR) represents a medical provocation for allergists and otorhinolaryngologists. LAR is considered to be a subtype of allergic rhinitis (AR) that affects a great percentage of patients who were, for decades, diagnosed as having chronic non-allergic rhinitis. The clinical picture is represented by rhinorrhea, sneezing, and nasal itching correlated with specific pollen season or dust, mold, or pet interior exposure.
View Article and Find Full Text PDFType 2 severe asthma: pathophysiology and treatment with biologics.
Expert Rev Respir Med
July 2024
Nuffield Department of Medicine, Respiratory Medicine Unit, University of Oxford, Oxford, UK.
Introduction: The hallmark of most patients with severe asthma is type 2 inflammation, driven by innate and adaptive immune responses leading to either allergic or non-allergic eosinophilic infiltration of airways. The cellular and molecular pathways underlying severe type 2 asthma can be successfully targeted by specific monoclonal antibodies.
Areas Covered: This review article provides a concise overview of the pathophysiology of type 2 asthma, followed by an updated appraisal of the mechanisms of action and therapeutic efficacy of currently available biologic treatments used for management of severe type 2 asthma.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!