AI Article Synopsis

  • - The rise of assisted reproductive technologies has resulted in a significant number of births, with most children being healthy, but concerns about procedural safety persist.
  • - A study analyzed 486 children born between 2010 and 2019 with developmental issues and found a higher occurrence of harmful genetic variants in those conceived via in vitro fertilization with donor eggs compared to natural conception.
  • - No similar genetic issues were found in children conceived using their own eggs, prompting the need for further research to understand the causes of genetic changes in donor oocyte cases and the potential for prenatal genetic screening.

Article Abstract

Development of assisted reproductive technologies to address infertility has favored the birth of many children in the last years. The majority of children born with these treatments are healthy, but some concerns remain on the safety of these medical procedures. We have retrospectively analyzed both the fertilization method and the microarray results in all those children born between 2010 and 2019 with multiple congenital anomalies, developmental delay and/or autistic spectrum disorder (n = 486) referred for array study in our center. This analysis showed a significant excess of pathogenic copy number variants among those patients conceived after in vitro fertilization with donor oocyte with respect to those patients conceived by natural fertilization (p = 0.0001). On the other hand, no significant excess of pathogenic copy number variants was observed among patients born by autologous oocyte in vitro fertilization. Further studies are necessary to confirm these results and in order to identify the factors that may contribute to an increased risk of genomic rearrangements, as well as consider the screening for genomic alterations after oocyte donation in prenatal diagnosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991411PMC
http://dx.doi.org/10.1038/s41598-021-86242-xDOI Listing

Publication Analysis

Top Keywords

pathogenic copy
12
copy number
12
number variants
12
donor oocyte
8
children born
8
excess pathogenic
8
patients conceived
8
vitro fertilization
8
prevalence pathogenic
4
children
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!