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Preclinical evaluation of the efficacy and safety of AAV8-TNAP-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia.
J Bone Miner Res
January 2025
Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP), with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4x108 up to 4x1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4x106 up to 4x109 (vg/b) was administered to 8-week-old AlplPrx1/Prx1 mice (a late-onset HPP model).
View Article and Find Full Text PDFModified Green-Ampt model for infiltration analysis in loess area and its parameter determination and verification.
Sci Rep
January 2025
School of Civil Engineering, Chang'an University, Xi'an, 710061, China.
Water infiltration into soil is important in geotechnical engineering. The classical Green-Ampt (GA) infiltration model is widely used in soil infiltration due to its physical significance, but it ignores the actual unsaturated layer in the infiltration process and has some deficiencies. Thus, the present study established a modified GA infiltration model (MLGA model) using Darcy's infiltration law and continuity equation to fully consider the variation characteristics of the soil water profile in the infiltration process.
View Article and Find Full Text PDFCross-calibration of areal bone mineral densities and body composition between DMS Stratos and Hologic Horizon A dual-energy X-ray absorptiometers: The effect of body mass index.
J Clin Densitom
December 2024
Service de Médecine Nucléaire, Hôpital Lapeyronie, CHU Montpellier, France; Physiologie et Médecine Expérimentale du Cœur et des Muscles (PhyMedEx), INSERM, CNRS, Université de Montpellier (UM), France.
Purpose: The aim of this study was to investigate the correlations between areal bone mineral density (aBMD) and body composition measured by two dual-energy X-ray absorptiometers (DXA), the DMS Stratos® (STR) and the Hologic Horizon A® (HRZ), and then generate cross-calibration equations between the two scanners.
Methods: Repeat scans were obtained from 251 adults (85 % female), 36 ± 14 years old with mean body mass index (BMI) of 28.7 ± 11.
A Cost-Effective Computational Strategy for the Electronic Layout Characterization of a Second Generation Light-Driven Molecular Rotary Motor in Solution.
J Comput Chem
January 2025
Scuola Superiore Meridionale, Napoli, Italy.
Light-driven molecular rotary motors are nanometric machines able to convert light into unidirectional motions. Several types of molecular motors have been developed to better respond to light stimuli, opening new avenues for developing smart materials ranging from nanomedicine to robotics. They have great importance in the scientific research across various disciplines, but a detailed comprehension of the underlying ultrafast photophysics immediately after photo-excitation, that is, Franck-Condon region characterization, is not fully achieved yet.
View Article and Find Full Text PDFPrior-FOVNet: A Multimodal Deep Learning Framework for Megavoltage Computed Tomography Truncation Artifact Correction and Field-of-View Extension.
Sensors (Basel)
December 2024
School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Megavoltage computed tomography (MVCT) plays a crucial role in patient positioning and dose reconstruction during tomotherapy. However, due to the limited scan field of view (sFOV), the entire cross-section of certain patients may not be fully covered, resulting in projection data truncation. Truncation artifacts in MVCT can compromise registration accuracy with the planned kilovoltage computed tomography (KVCT) and hinder subsequent MVCT-based adaptive planning.
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