AI Article Synopsis

  • Research suggests that inflammation may play a significant role in the cognitive and neurological changes associated with schizophrenia, including increased peripheral inflammation and cortical thinning.
  • A study involving 644 controls and 499 schizophrenia patients found that levels of C-reactive protein (CRP), a marker of inflammation, were significantly higher in schizophrenia patients and linked to attention deficits and reduced cortical thickness in specific brain regions.
  • These findings highlight the potential of using CRP as a biomarker to identify individuals with schizophrenia who may benefit from anti-inflammatory treatments, indicating a connection between inflammation and cognitive impairment in the disorder.

Article Abstract

While the biological substrates of brain and behavioural changes in persons with schizophrenia remain unclear, increasing evidence implicates that inflammation is involved. In schizophrenia, including first-episode psychosis and anti-psychotic naïve patients, there are numerous reports of increased peripheral inflammation, cognitive deficits and neuropathologies such as cortical thinning. Research defining the relationship between inflammation and schizophrenia symptomatology and neuropathology is needed. Therefore, we analysed the level of C-reactive protein (CRP), a peripheral inflammation marker, and its relationship with cognitive functioning in a cohort of 644 controls and 499 schizophrenia patients. In a subset of individuals who underwent MRI scanning (99 controls and 194 schizophrenia cases), we tested if serum CRP was associated with cortical thickness. CRP was significantly increased in schizophrenia patients compared to controls, co-varying for age, sex, overweight/obesity and diabetes (p < 0.006E-10). In schizophrenia, increased CRP was mildly associated with worse performance in attention, controlling for age, sex and education (R =- 0.15, p = 0.001). Further, increased CRP was associated with reduced cortical thickness in three regions related to attention: the caudal middle frontal, the pars opercularis and the posterior cingulate cortices, which remained significant after controlling for multiple comparisons (all p < 0.05). Together, these findings indicate that increased peripheral inflammation is associated with deficits in cognitive function and brain structure in schizophrenia, especially reduced attention and reduced cortical thickness in associated brain regions. Using CRP as a biomarker of peripheral inflammation in persons with schizophrenia may help to identify vulnerable patients and those that may benefit from adjunctive anti-inflammatory treatments.

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Source
http://dx.doi.org/10.1007/s00406-021-01237-zDOI Listing

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