A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N-O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252732 | PMC |
| http://dx.doi.org/10.1002/anie.202100801 | DOI Listing |
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