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Unlabelled: Caliciviruses are significant agricultural and human pathogens that are poorly understood due to the dearth of molecular tools, including reporter systems. We report the development of a stable, faithful, and robust luciferase-based reporter system for a model calicivirus, murine norovirus (MNoV). Genetic insertion of a HiBiT tag, an 11 amino acid fragment of nanolucifersase, at the junction of the nonstructural proteins NS4 and NS5 yields infectious virus.
View Article and Find Full Text PDFThe Holistic Effect of Complementary Interventions in Reducing Stress in College Students.
J Holist Nurs
January 2025
Cleveland Clinic Foundation, Cleveland, OH, USA.
The purpose of this research was to examine the holistic effects of combined complementary therapies in reducing stress in college students. This convergent mixed-method study provided aromatherapy, massage, and meditation music sessions to college students ( = 50) just before finals week. Paired t-tests analyzed pre-session and post-session perceived stress and anxiety as well as objective physiological measures, including salivary cortisol, heart rate, and blood pressure.
View Article and Find Full Text PDFPranayama (yogic breathing practices) in Parkinson's disease: protocol for a scoping review of literature.
BMJ Open
December 2024
Dr D Y Patil Vidyapeeth, Dr D Y Patil Medical College Hospital and Research Centre, Pune, Maharashtra, India.
Introduction: Parkinson's disease is a neurodegenerative disorder that presents with motor symptoms such as tremors, slowness and gait difficulties, in addition to various non-motor symptoms such as anxiety, depression and autonomic and sleep disturbances. Pranayama (yogic breathing practices) has been studied as a part of yoga interventions in Parkinson's disease. Previous systematic reviews and meta-analyses have not detailed the pranayama practices used in clinical studies, and there is no clarity on the pranayama practices that would be most beneficial for Parkinson's disease.
View Article and Find Full Text PDFAdd on effect of Whole System Ayurveda protocol in suboptimal controlled Primary Hypothyroidism - A randomized controlled trial.
J Ayurveda Integr Med
January 2025
Department of Kayachikitsa, Shri BMK Ayurveda Mahavidyalaya, A Constituent Unit of KLE Academy of Higher Education & Research, Belagavi Karnataka, 590003, India. Electronic address:
Background: Primary hypothyroidism (PH) is a common chronic life style disorder. Whole system Ayurveda protocol on PH (WSAPH) is explored for it's possible complimentary role in the management of suboptimal controlled PH on stable levothyroxine therapy.
Objective: To evaluate the efficacy of whole system Ayurveda protocol on Primary hypothyroidism with suboptimal response to stable levothyroxine therapy.
Management of acute myocardial infarction in chronic kidney disease in Germany: an observational study.
BMC Nephrol
January 2025
Department of Internal Medicine II, Universitätsmedizin (Halle), Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
Background: Managing acute myocardial infarction (AMI) in patients with chronic kidney disease (CKD) or end-stage renal disease on dialysis (renal replacement therapy, RRT) presents challenges due to elevated complication risks. Concerns about contrast-related kidney damage may lead to the omission of guideline-directed therapies like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in this population.
Methods: We analysed German-DRG data of 2016 provided by the German Federal Bureau of Statistics (DESTATIS).
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