Tackling hyperarousal: an integrative multimodal approach.

The effectiveness of treatment for PTSD is limited, which is especially true for war veterans, of whom 30-50% do not respond to therapy. Hyperarousal is central to the maintenance of trauma pathology. The mainstream trauma-focused therapies traditionally target the cognitive processing of traumatic experience. In this article, we propose that these therapies may be enhanced by the inclusion of interventions specifically targeting hyperarousal. We review an earlier formulated model of trauma supporting our proposal. This model is based on a theory of trauma that integrates the concept of allostasis with the predictive processing framework. In this view, trauma is considered a maladaptive stress response guided by false inference. The reviewed model is in agreement with the central role of hyperarousal in the maintenance of trauma-induced disorders. It also demonstrates the importance of targeting hyperarousal at the same time as maladaptive cognitions and behaviours associated with trauma. A treatment for PTSD is proposed that combines exposure to trauma-related cues with neurofeedback-mediated regulation of arousal. Our analysis argues for the integration of hyperarousal-targeting interventions into existing therapies. Accordingly, we offer methodological considerations based on the nested hierarchy principle that can guide such integration.