AI Article Synopsis
- R-loops are RNA:DNA hybrids that can lead to genetic instability if not formed correctly, and they play a crucial role in the repair of DNA double-strand breaks (DSBs).
- BRCA1, a multifunctional protein, is recruited to these R-loops at DSBs, helping to regulate their removal to ensure proper DNA repair.
- The review examines BRCA1’s various roles in maintaining R-loop balance during the DNA repair process to ensure accurate DSB resolution.
Article Abstract
R-loops are RNA:DNA hybrids assembled during biological processes but are also linked to genetic instability when formed out of their natural context. Emerging evidence suggests that the repair of DNA double-strand breaks requires the formation of a transient R-loop, which eventually must be removed to guarantee a correct repair process. The multifaceted BRCA1 protein has been shown to be recruited at this specific break-induced R-loop, and it facilitates mechanisms in order to regulate R-loop removal. In this review, we discuss the different potential roles of BRCA1 in R-loop homeostasis during DNA repair and how these processes ensure faithful DSB repair.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136775 | PMC |
| http://dx.doi.org/10.1093/nar/gkab178 | DOI Listing |
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