AI Article Synopsis
- Burkholderia pseudomallei sequence type 562 (ST562) has spread across northern Australia since 2005, causing melioidosis in 61 humans and 3 animals from 2005 to 2019.
- Initially concentrated around a creek, cases have increased, with ST562 accounting for 12% of melioidosis cases in urban Darwin.
- Genetic analysis revealed connections between ST562 strains in Australia and those from Hainan Province, China, and Pingtung County, Taiwan, suggesting a potential single introduction into Darwin around 1988, though its exact origin and transmission remain unclear.
Article Abstract
Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007296 | PMC |
| http://dx.doi.org/10.3201/eid2704.202716 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!