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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.
View Article and Find Full Text PDFDiscarded sequencing reads uncover natural variation in pest resistance in .
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Plant Evolutionary Ecology, Institute of Evolution and Ecology, University of Tübingen, Tübingen, Germany.
Understanding the genomic basis of natural variation in plant pest resistance is an important goal in plant science, but it usually requires large and labor-intensive phenotyping experiments. Here, we explored the possibility that non-target reads from plant DNA sequencing can serve as phenotyping proxies for addressing such questions. We used data from a whole-genome and -epigenome sequencing study of 207 natural lines of field pennycress () that were grown in a common environment and spontaneously colonized by aphids, mildew, and other microbes.
View Article and Find Full Text PDFThe acoel worm has recently emerged as a model organism for studying whole-body regeneration and embryonic development. Previous studies suggest that post-transcriptional mechanisms likely play important roles in whole-body regeneration. Here, we establish a resource for studying microRNA-mediated gene regulation, a major aspect of post-transcriptional control in animals.
View Article and Find Full Text PDFEfficacy of add-on Cenobamate treatment in refractory epilepsy due to Rasmussen's encephalitis.
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December 2024
European Reference Network EpiCare, Europe.
Article Synopsis
- The study assesses the effectiveness of cenobamate, a new antiseizure medication, in treating three patients with the severe epilepsy syndrome linked to Rasmussen's encephalitis, which had previously resisted over 10 treatments.
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