Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10123-021-00171-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Changing the paradigm of soft contact lens fitting: A sagittal height-based approach.
Ophthalmic Physiol Opt
March 2025
Department of Optics, Faculty of Sciences, University of Granada, Granada, Spain.
Objective: The present study evaluated the correlation between ocular sagittal height and lens sagittal depth, specifically focusing on the sagittal difference (δ-sag) that defines an optimal lens fit.
Methods: The ocular sagittal height (spanning a 14.2-mm chord in the ocular surface flattest meridian) of 30 subjects was measured using the Oculus Pentacam HR.
Clinical Analyses of 4 Cases of Microsporidial Keratoconjunctivitis.
Acta Parasitol
March 2025
The Department of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, 138 Han-zhong Road, Nanjing, 210029, China.
Objective: To report four cases of microsporidial keratoconjunctivitis (MKC) from The Affiliated Eye Hospital of Nanjing Medical University (from May 2023 to October 2024) and to aid ophthalmologists in diagnosing and treating MKC, as MKC has been increasingly reported in Asian healthy individuals but not much in Mainland China.
Methods: Four patients with MKC were studied. Demographic information, symptoms, and clinical data were collected.
Paired eye comparison of baseline parameters and tomographic characteristics prior to hydrops in patients with keratoconus.
Int Ophthalmol
March 2025
Faculty, Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, 500034, India.
Purpose: To characterise the baseline parameters and tomographic features prior to hydrops in patients with keratoconus.
Methods: Of the 190 patients diagnosed with hydrops, during the study period between 2015 and 2022, 55 eyes of 55 patients who had corneal tomography in both eyes prior to developing hydrops were included in this study. Comparison of clinical and tomography parameters between the eyes was performed.
Topical Cenegermin-Bkbj Dramatically Resolves Neurotrophic Keratitis Associated With Pars Plana Vitrectomy.
Ophthalmic Surg Lasers Imaging Retina
March 2025
Neurotrophic keratitis (NK) may occur secondary to pars plana vitrectomy (PPV). A subset of patients with very severe NK corneal defects may require therapy escalation, and Cenegermin-Bkbj, a recombinant human nerve growth factor, represents a novel treatment option. This case report presents the successful treatment of refractory NK using Cenegermin-Bkbj in a patient after undergoing multiple PPV surgeries.
View Article and Find Full Text PDFMaking a Family: Kinning and Conception in Lesbian Families.
J Homosex
March 2025
Swedish Institute for Social Research, Stockholm University, Stockholm, Sweden.
In the Netherlands, lesbian couples have a relatively high level of agency in shaping conception, as they can choose between different donor constructions (sperm bank donor versus contact donor), high- and low-tech medical interventions, and clinical and non-clinical inseminations. This results in pluriform conceptive practices, which this paper examines through the lens of , i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!