An analytical model is developed to predict shockwave propagation and attenuation in hydrogels by combining the classical method of shock characteristics and a solution for the shock front structure. To guide the development of the model, molecular dynamics (MD) simulations are performed. Specifically, a one-dimensional shock pulse in poly(ethylene glycol) diacrylate (PEGDA) hydrogels is simulated with the nonequilibrium MD method. The role of polymer concentration on the shock response is evaluated by constructing hydrogels with 20, 35, and 50 wt% PEGDA concentrations in an idealized crosslinked network. Steady-state pressure-density and shock-particle velocity relationships are established using the Murnaghan equation of state. Shock front structure is characterized by a power-law equation that relates the shock front thickness with shock pressure. These results are used as critical input for the shock propagation and attenuation model. The model is then evaluated via comparison with the classical method of characteristics. It shows significant improvement in accuracy and successfully captures salient features of shockwave attenuation, including the shock pressure amplitude, the velocities of the shock and release waves, and the attenuation timeline. Hydrogels with higher polymer concentrations exhibit a shorter attenuation time at all particle velocities studied. This behavior is attributed to differences in bulk properties and shock front structure in hydrogels with different polymer/water concentrations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jmbbm.2021.104423 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Developing and validating a machine learning model to predict multidrug-resistant -related septic shock.
Front Immunol
January 2025
Department of Medical Laboratory, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections pose a significant global healthcare challenge, particularly due to the high mortality risk associated with septic shock. This study aimed to develop and validate a machine learning-based model to predict the risk of MDR-KP-associated septic shock, enabling early risk stratification and targeted interventions.
Methods: A retrospective analysis was conducted on 1,385 patients with MDR-KP infections admitted between January 2019 and June 2024.
Effect of taurine supplementation on preventing ventilator-associated pneumonia in pediatrics under mechanical ventilation, a randomized controlled double-blind clinical trial.
Front Pediatr
January 2025
Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: One of the most prevalent healthcare-associated infections in the pediatric intensive care unit is ventilator-associated pneumonia (VAP). VAP not only results in prolonged hospital and intensive care unit (ICU) stays but also imposes higher costs on patients and the healthcare system. Therefore, it is essential to implement preventive measures.
View Article and Find Full Text PDFAortoiliac arterial thrombosis and renal artery stenosis in a patient with neonatal multisystem inflammatory syndrome: a case report and review of literature.
Front Pediatr
January 2025
Division of Neonatology, Department of Pediatrics, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Background: Multisystem inflammatory syndrome in neonates (MIS-N) is a rare condition thought to be associated with prenatal exposure to maternal severe acute respiratory syndrome coronavirus 2 infection. This immune-mediated hyperinflammation has been described in neonates with multiorgan dysfunction, including cardiopulmonary, encephalopathy, coagulopathy, and vascular complications. However, renovascular complications in MIS-N are rare.
View Article and Find Full Text PDFDeveloping affordable and efficient heating devices for enhanced live cell imaging in confocal microscopy.
Front Plant Sci
January 2025
Department of Biology, University of Mississippi, University, MS, United States.
Temperature control is crucial for live cell imaging, particularly in studies involving plant responses to high ambient temperatures and thermal stress. This study presents the design, development, and testing of two cost-effective heating devices tailored for confocal microscopy applications: an aluminum heat plate and a wireless mini-heater. The aluminum heat plate, engineered to integrate seamlessly with the standard 160 mm × 110 mm microscope stage, supports temperatures up to 36°C, suitable for studies in the range of non-stressful warm temperatures (e.
View Article and Find Full Text PDFHSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms.
Front Cell Dev Biol
January 2025
Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States.
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1's role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1's function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!